Journal of Applied Phycology

, Volume 27, Issue 4, pp 1599–1605 | Cite as

Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds

  • Kannan R. R. Rengasamy
  • Stephen O. Amoo
  • Adeyemi O. Aremu
  • Wendy A. Stirk
  • Jiří Gruz
  • Michaela Šubrtová
  • Karel Doležal
  • Johannes Van Staden
Article

Abstract

In the search for new, safe, and natural sources as antioxidant and acetylcholinesterase (AChE) inhibitors, eight seaweeds were collected from the intertidal region in KwaZulu-Natal, South Africa and screened. Their total phenolic, flavonoid, and condensed tannin contents were determined, and the specific phenolic acids were identified. The highest total phenolics, flavonoids, and condensed tannin were recorded in Rhodomelopsis africana (7.89 mg gallic acid equivalents g−1), Halimeda cuneata (3.64 mg catechin equivalents g−1), and Codium duthieae (0.60 mg cyanide chloride equivalents g−1), respectively. Based on UHPLC-MS/MS, different concentrations of protocatechuic acid, p-hydroxybenzoic acid, and m-hydroxybenzoic acid were quantified in the seaweeds. The highest radical scavenging ability and oxygen radical absorbance capacity (ORAC) were observed in red Gelidium foliaceum (52.2 %) and green C. duthieae (44 μmol TE g−1), respectively. In terms of AChE inhibition, the green H. cuneata exhibited greatest bioactivity (IC50 = 70 μg mL−1). Overall, the findings suggest that these seaweeds could be potential candidates as new sources of natural antioxidant and AChE inhibitors.

Keywords

Alzheimer’s disease AChE inhibitors Phenolics Macroalgae UHPLC-MS/MS 

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Kannan R. R. Rengasamy
    • 1
  • Stephen O. Amoo
    • 1
  • Adeyemi O. Aremu
    • 1
  • Wendy A. Stirk
    • 1
  • Jiří Gruz
    • 2
  • Michaela Šubrtová
    • 2
  • Karel Doležal
    • 2
  • Johannes Van Staden
    • 1
  1. 1.Research Centre for Plant Growth and Development, School of Life SciencesUniversity of KwaZulu-Natal PietermaritzburgScottsvilleSouth Africa
  2. 2.Laboratory of Growth Regulators & Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of SciencePalacký University & Institute of Experimental Botany AS CROlomoucCzech Republic

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