Journal of Analytical Chemistry

, Volume 60, Issue 9, pp 822–827 | Cite as

Simple Sensitive Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

  • G. Krishnamurthy Naidu
  • K. Suvardhan
  • K. Suresh Kumar
  • D. Rekha
  • B. S. Sastry
  • P. Chiranjeevi
Articles

Abstract

A novel coupling reagent was used for simple, rapid, and sensitive spectrophotometric determination of isoniazid (1NH) and ritodrine hydrochloride (RTH) in pure form or in pharmaceutical preparations of it. The method is based on the diazotization of 4,4-methylene-bis-m-nitroaniline followed by a coupling reaction with either INH or RTH in hydrochloric acid medium. The resulting colored products have absorption maxima at 495 and 473 nm, respectively. Beer's law is obeyed in the concentration ranges of 0.1–15 µg/mL and 0.1–17 µg/mL. The method is applied for the analysis of INH/RTH in pharmaceutical preparations and the results agree favorably with the official and reported data. Common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method offers the advantages of simplicity, rapidity, and sensitivity without the need of extraction or heating.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Nagaraja, P., Srinivasamurthy, K.C., and Yathirajan, H.S., Talanta, 1996, vol. 43, p. 1075.CrossRefGoogle Scholar
  2. 2.
    Nayak, A.N., Yathirajan, H.S., and Manjappa, S., Curr. Sci., 1981, vol. 50, p. 812.Google Scholar
  3. 3.
    Kovatscheva, E., Aleksandrova, P.V., and Ivanova, V., Mikrochim. Acta, 1983, vol. 113, p. 483.CrossRefGoogle Scholar
  4. 4.
    Fujita, Y., Mori. I., and Kitano, S., Bunseki Kagaku, 1983, vol. 32, p. 199.Google Scholar
  5. 5.
    El Kommos, M.E. and Yanni, A.S., Analyst, 1988, vol. 113, p. 109.CrossRefPubMedGoogle Scholar
  6. 6.
    Csiba, A., Acta Pharm. Hung., 1989, vol. 59, p. 205.PubMedGoogle Scholar
  7. 7.
    Hassan, H.Y., Mohamed, A.M., and Mohamed, F.A., Anal. Lett., 1990, vol. 23, p. 617.Google Scholar
  8. 8.
    Mohamed, Z.H., El Sayed, L., and Wahbi, A.A., Egypt. J. Pharm. Sci., 1989, vol. 30, p. 43.Google Scholar
  9. 9.
    Issopoulos, P.B., Int. J. Pharm., 1991, vol. 70, p. 201.CrossRefGoogle Scholar
  10. 10.
    Issopoulos, P.B., Acta Pharm. Hung., 1991, vol. 61, p. 198.Google Scholar
  11. 11.
    Ahmed, A.H., El Gizawy, S.M., and El Subbagh, H.I., Anal. Lett., 1992, vol. 25, p. 73.Google Scholar
  12. 12.
    Sastry, C.S.P., Srinivas, K.R., and Krishnaprasad, M.M., Mikrochim. Acta, 1996, vol. 122, p. 77.CrossRefGoogle Scholar
  13. 13.
    Sastry, C.S.P., Chintalapati, R., Prasad, A.V.S.S., and Sastry, B.S., Talanta, 2001, vol. 53, p. 907.CrossRefGoogle Scholar
  14. 14.
    Revanasiddappa, H.D., Manju, B., and Ramappa, P.G., Anal. Sci., 1999, vol. 15, p. 661.CrossRefGoogle Scholar
  15. 15.
    Revanasiddappa, H.D. and Manju, B., J. Assoc. Anal. Chem., 2000, vol. 83, p. 1440.Google Scholar
  16. 16.
    Bakry, R.S., El Walily, A.F.M., and Belal, S.F., Mikrochim. Acta, 1997, vol. 127, p. 89.CrossRefGoogle Scholar
  17. 17.
    United States Pharmacopoeia XXIV, Rockville: U.S.P. Convention, 2000, p. 408.Google Scholar
  18. 18.
    United States Pharmacopoeia XXIV, Rockville: U.S.P. Convention, 2000, p. 1493.Google Scholar
  19. 19.
    Nagaraja, P., Sunitha, K.R., and Silwadi, M.F., J. Pharm. Biomed. Anal., 2000, vol. 23, p. 617.CrossRefPubMedGoogle Scholar
  20. 20.
    Nagaraja, P., Vasantha, R.A., and Sunitha, K.R., J.Pharm. Biomed. Anal., 2001, vol. 25, p. 417.CrossRefPubMedGoogle Scholar
  21. 21.
    Nagaraja, P., Vasantha, R.A., and Yathirajan, H.S., J. Pharm. Biomed. Anal., 2002, vol. 28, p. 161.CrossRefPubMedGoogle Scholar
  22. 22.
    Nagaraja, P., Sunitha, K.R., Vasantha, R.A., and Yathirajan, H.S., Eur. J. Pharm. Biopharm., 2002, vol. 53, p. 187.CrossRefPubMedGoogle Scholar
  23. 23.
    Nagaraja, P., Arunkumar, H.S., Vasantha, R.A., and Yathirajan, H.S., Int. J. Pharm., 2002, vol. 235, p. 113.CrossRefPubMedGoogle Scholar
  24. 24.
    Nagaraja, P., Yathirajan, H.S., Sunitha, K.R., and Vasantha, R.A., J. Assoc. Anal. Chem., 2002, vol. 85.Google Scholar
  25. 25.
    Nagaraja, P., Sunitha, K.R., Vasantha, R.A., and Yathirajan, H.S., J. Pharm. Biomed. Anal., 2002, vol. 28, p. 527.CrossRefPubMedGoogle Scholar
  26. 26.
    Nagaraja, P., Yathirajan, H.S., Arunkumar, H.R., and Vasantha, R.A., J. Pharm. Biomed. Anal., 2002, vol. 29, p. 277.CrossRefPubMedGoogle Scholar

Copyright information

© MAIK "Nauka/Interperiodica" 2005

Authors and Affiliations

  • G. Krishnamurthy Naidu
    • 1
  • K. Suvardhan
    • 1
  • K. Suresh Kumar
    • 1
  • D. Rekha
    • 1
  • B. S. Sastry
    • 2
  • P. Chiranjeevi
    • 3
  1. 1.S.V. Govt. PolytechnicTiTTipati, A.P.India
  2. 2.Department of Pharmaceutical SciencesAndhra UniversityVisakhapatnam, A.P.India
  3. 3.Environmental Monitoring Laboratory, Department of ChemistryS.V. UniversityTirupati, A.P.India

Personalised recommendations