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Temperament as an Early Risk Marker for Autism Spectrum Disorders? A Longitudinal Study of High-Risk and Low-Risk Infants

  • M. K. J. PijlEmail author
  • G. Bussu
  • T. Charman
  • M. H. Johnson
  • E. J. H. Jones
  • G. Pasco
  • I. J. Oosterling
  • N. N. J. Rommelse
  • J. K. Buitelaar
  • The BASIS Team
Original Article

Abstract

To investigate temperament as an early risk marker for autism spectrum disorder (ASD), we examined parent-reported temperament for high-risk (HR, n = 170) and low-risk (LR, n = 77) siblings at 8, 14, and 24 months. Diagnostic assessment was performed at 36 months. Group-based analyses showed linear risk gradients, with more atypical temperament for HR-ASD, followed by HR-Atypical, HR-Typical, and LR siblings. Temperament differed significantly between outcome groups (0.03 ≤ ηp2 ≤ 0.34). Machine learning analyses showed that, at an individual level, HR-ASD siblings could not be identified accurately, whereas HR infants without ASD could. Our results emphasize the discrepancy between group-based and individual-based predictions and suggest that while temperament does not facilitate early identification of ASD individually, it may help identify HR infants who do not develop ASD.

Keywords

Autism spectrum disorder High-risk Temperament Longitudinal Machine learning 

Notes

Acknowledgments

The data included in this study were collected by the British Autism Study of Infant Siblings (BASIS, http://www.basisnetwork.org) project as part of a larger study. We gratefully thank all parents and children who participated in this study. The research leading to these results received support from MRC Programme grants (G0701484 and MR/K021389/1) to MHJ, and the BASIS funding consortium led by Autistica. This research has also received funding from the Innovative Medicines Initiative Joint Undertaking under grant agreement number 115300 (EU-AIMS), resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and the European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in kind contribution. The research was further supported by the Marie Sklodowska Curie Actions of the European Community’s Horizon 2020 Program under grant agreement n°642996 (Brainview). The BASIS Team in alphabetical order: Phase 1: Baron-Cohen, S., Bedford, R., Bolton, P., Chandler, S., Elsabbagh, M., Fernandes, J., Garwood, H., Gliga, T., Hudry, K., Pickles, A., Tucker, L., Volein, A.; Phase 2: Baron-Cohen, S., Bedford, R., Bolton, P., Blasi, A., Cheung, C., Davies, K., Elsabbagh, M., Fernandes, J., Gammer, I., Gliga, T., Guiraud, J., Liew, M., Lloyd-Fox, S., M.H., Maris, H., O’Hara, L., Pickles, A., Ribeiro, H., Salomone, E., Tucker, L.

Author Contributions

TC, MHJ, and EJHJ designed the study leading to the data included in the current work, and developed acquisition protocols. Data were collected from the BASIS team. GP was involved in data collection and processing. MKJP performed statistical analysis, interpreted data, and drafted the first and final version of the manuscript. GB performed statistical analysis and interpretation for individual prediction. JKB, NNJR, and IJO helped data interpretation. All authors read and approved the final version.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

10803_2018_3855_MOESM1_ESM.docx (223 kb)
Supplementary material 1 (DOCX 222 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • M. K. J. Pijl
    • 1
    • 2
    Email author
  • G. Bussu
    • 1
  • T. Charman
    • 3
  • M. H. Johnson
    • 4
    • 5
  • E. J. H. Jones
    • 4
  • G. Pasco
    • 3
  • I. J. Oosterling
    • 2
  • N. N. J. Rommelse
    • 2
    • 6
  • J. K. Buitelaar
    • 1
    • 2
  • The BASIS Team
  1. 1.Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and BehaviourRadboud University Medical CentreNijmegenThe Netherlands
  2. 2.Karakter Child and Adolescent Psychiatry University CentreNijmegenThe Netherlands
  3. 3.Psychology Department, Institute of Psychiatry, Psychology & NeuroscienceKing’s College LondonLondonUK
  4. 4.Centre for Brain and Cognitive Development, Birkbeck CollegeUniversity of LondonLondonUK
  5. 5.Psychology DepartmentUniversity of CambridgeCambridgeUK
  6. 6.Department of PsychiatryRadboud University Medical CentreNijmegenThe Netherlands

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