Skip to main content
Log in

The Clinical Features of Comorbid Pediatric Bipolar Disorder in Children with Autism Spectrum Disorder

  • Original Paper
  • Published:
Journal of Autism and Developmental Disorders Aims and scope Submit manuscript

Abstract

The aim of this study was to describe clinical features of PBD comorbidity in children with ASD. Forty children with ASD and PBD aged 6–18 years, and 40 age- and sex-matched ASD subjects with no affective episodes were included in the study. Autism Behavior CheckList, Abberant Behavior CheckList, and Young Mania Rating Scale-Parent Version were completed. This study shows that PBD comorbidity in children with ASD involves a highly episodic course, with manic episodes, subsyndromal symptoms and interepisodic periods commonly being described in the manic symptom profile of these children. These findings need to be repeated with large samples, together with controlled studies concerning therapeutic interventions directed toward PBD comorbidity in children with ASD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Aman, G. M., Singh, N. N., Stewart, A. W., et al. (1985). The Aberrant Behavior Checklist. American Journal of Mental Deficiency, 89(5), 485–491.

    PubMed  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statictical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association.

    Book  Google Scholar 

  • Boso, M., Comelli, M., Emanuele, E., et al. (2010). Seasonal fluctuations in problem behaviors among young adults with autism and intellectual disability. Medical Science Monitor, 16(5), 213–216.

    Google Scholar 

  • De Bruin, E., Ferdinand, R., Meester, S., et al. (2007). High rates of psychiatric comorbidity in PDD-NOS. Journal of Autism and Developmental Disorders, 37(5), 877–886.

    Article  PubMed  Google Scholar 

  • Dejong, S., & Frazier, J. A. (2003). Bipolar disorder in children with pervasive developmental disorders. In M. P. DelBello & B. Geller, Bipolar disorder in childhood and early adolescence. New York: The Guilford Press.

    Google Scholar 

  • Diler, R. S., Uğuz, S., Seydaoğlu, G., et al. (2007). Differentiating bipolar disorder in Turkish prepubertal children with attention-deficit hyperactivity disorder. Bipolar Disorders, 9, 243–251.

    Article  PubMed  Google Scholar 

  • Faeda, G. L., Baldesarrini, R. J., Glovinski, I. P., et al. (2004). Pediatric bipolar disorder; phenomenology and course of illnes. Bipolar Disorders, 6(4), 305–313.

    Article  Google Scholar 

  • Findling, R. L., Gracious, B. L., & McNamara, N. K. (2001). Rapid, continuous cycling and psychiatric comorbidity in pediatric bipolar I disorder. Bipolar Disorders, 3(4), 202–210.

    Article  PubMed  Google Scholar 

  • Frazier, J. A., Doyle, R., Chiu, S., & Coyle, J. T. (2002). Treating a child with Asperger’s disorder and comorbid Bipolar Disorder. American Journal of Psychiatry, 159(1), 13–21.

    Article  PubMed  Google Scholar 

  • Ghaziuddin, M., Weidmer-Mikhail, E., & Ghaziuddin, N. (1998). Comorbidity of Asperger sydrome; a preliminary report. Journal of Intellectual Disability Research, 42(4), 279–283.

    Article  PubMed  Google Scholar 

  • Gökler, B., Ünal, F., Pehlivantürk, B., et al. (2004). Okul Çağı Çocukları için Duygulanım Bozuklukları ve Şizofreni Görüşme Çizelgesi-Şimdi ve Yaşamboyu Şekli-Türkçe Uyarlamasının Geçerliliği ve Güvenilirliği. Çocuk ve Gençlik Ruh Sağlığı Dergisi, 11(3), 109–116.

    Google Scholar 

  • Gracious, B. L., Youngstrom, E. A., Findling, R. L., et al. (2002). Discriminative validity of a parent version of the Young Mania Rating Scale. Journal of the American Academy Child Adolescence Psychiatry, 41(11), 1350–1359.

    Article  Google Scholar 

  • Hayashi, E. (2001). Seasonal changes in sleep and behavioral problems in a pubescent case with autism. Psychiatry and Clinical Neurosciences, 55(3), 223–224.

    Article  PubMed  Google Scholar 

  • Hofvander, B., Delorme, R., Chaste, P., et al. (2009). Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disorders. BMC Psychiatry, 9, 35.

    Article  PubMed  PubMed Central  Google Scholar 

  • Howell, C., Larson, J., & Coffey, B. J. (2011). Treatment of bipolar disorder in an adolescent with autistic disorder: A diagnostic and treatment dilemma. Journal of Child and Adolescent Psychopharmacology, 21(3), 283–286.

    Article  PubMed  Google Scholar 

  • Hutton, J., Goode, S., Murphy, M., et al. (2008). New-onset psychiatric disorders in individuals with autism. Autism, 12(4), 373–390.

    Article  PubMed  Google Scholar 

  • Joshi, G., Biederman, J., Petty, C., et al. (2013). Examining the comorbidity of bipolar disorder and autism spectrum disorders: A large controlled analysis of phenotypic and familial correlates in a referred population of youth with bipolar i disorder with and without autism spectrum disorders. Journal of Clinical Psychiatry, 74(6), 578–586.

    Article  PubMed  Google Scholar 

  • Kaat, A. J., Lecavalier, L., & Aman, M. G. (2014). Validity of the Aberrant Behavior Checklist in children with autism spectrum disorder. Journal of Autism and Developmental, Disorders44(5), 1103–1116.

    Article  Google Scholar 

  • Kaufman, J., Birmaher, B., & Brent, D. (1997). Schedule for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy Child Adolescence Psychiatry, 36(7), 980–988.

    Article  Google Scholar 

  • King, R., Fay, G., & Croghan, P. (2000). Rapid cycling bipolar disorder in individuals with developmental disabilities. Mental Retardation, 38(3), 253–261.

    Article  PubMed  Google Scholar 

  • Krug, D. A., Arick, J., & Almond, P. (1980). Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry, 21(3), 221–229.

    Article  PubMed  Google Scholar 

  • Kurita, H., & Nakayasu, N. (1994). Brief report: An autistic male presenting seasonal affective disorder and trichotillomania. Journal of Autism and Developmental Disorders, 24(5), 687–692.

    Article  PubMed  Google Scholar 

  • Kurita, H., Osada, H., Shimizu, K., et al. (2004). Bipolar disorders in mentally retarded persons with pervasive developmental disorders. Journal of Developmental and Physical Disabilities, 16(4), 377–389.

    Article  Google Scholar 

  • Lainhart, J. E., & Folstein, S. E. (1994). Affective disorders in people with autism: A review of published cases. Journal of Autism and Developmental Disorders, 24(5), 587–601.

    Article  PubMed  Google Scholar 

  • Leyfer, O., Folstein, S., Bacalman, S., et al. (2006). Comorbid psychiaytric disorders in children with autism: Interview development and rates of disorders. Journal of Autism and Developmental Disorders, 36(7), 849–861.

    Article  PubMed  Google Scholar 

  • LoVullo, S. V., & Matson, J. L. (2009). Comorbid psychopathology in adults with autism spectrum disorders and intellectual disabilities. Research in Developmental Disabilities, 30(6), 1288–1296.

    Article  PubMed  Google Scholar 

  • Lugnegard, T., Hallerback, M. U., & Gillberg, C. (2011). Psychiatric comorbidity in young adults with clinical diagnosis of Asperger syndrome. Research in Developmental Disabilities, 32(5), 1910–1917.

    Article  PubMed  Google Scholar 

  • Mazefksky, C., Oswald, D., Day, T., et al. (2012). ASD, a psychiatric disorder, or both? psychiatric diagnoses in adolescents with high functioning ASD. Journal of Clinical Child and Adolescent Psychology, 41(4), 516–523.

    Article  Google Scholar 

  • Mukaddes, N. M. (2013). Otizm Spektrum Bozuklukları: Tanı ve Takip. İstanbul: Nobel Tıp Kitabevleri.

    Google Scholar 

  • Mukaddes, N. M., & Fateh, R. (2010). High Rates of Psychiatric comorbidity in individuals with Asperger’s disorder. The World Journal of Biological Psychiatry, 11(2), 486–492.

    Article  PubMed  Google Scholar 

  • Munesue, T., Ono, Y., Mutoh, K., et al. (2008). High prevalance of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: A preliminary study of 44 outpatients. Journal of Affective Disorders, 111(2–3), 170–175.

    Article  PubMed  Google Scholar 

  • Pavuluri, M. N., Hendry, D. B., & Carbray, J. A. (2005). Divalproex sodium for pediatric mixed mania: A 6 month prospective trial. Bipolar Disorders, 7(3), 266–273.

    Article  PubMed  Google Scholar 

  • Sucuoğlu, B. (2003). Sorun Davranışları Kontrol Listesi Türkçe Formunun Psikometrik Özelliklerinin İncelenmesi. Türk Psikoloji Dergisi, 18(52), 77–91.

    Google Scholar 

  • Vanucchi, G. (2014). Bipolar disorder in adults with Asperger’s syndrome: A systematic review. Journal of Affective Disorders, 168, 151–160.

    Article  Google Scholar 

  • Wozniak, J., Biederman, J., Faraone, S. V., et al. (1997). Mania in children with pervasive developmental disorder revisited. Journal of the American Academy Child Adolescence Psychiatry, 36(11), 1552–1559.

    Google Scholar 

  • Wozniak, J., Biederman, J., & Kiely, K. (1995). Mania like symptom suggestive of childhood-onset bipolar disorder in clinically referred sample. Journal of the American Academy of Child and Adolescence Psychiatry, 34(7), 867–876.

    Article  Google Scholar 

  • Yılmaz, I. T., Tekinsav, S. S., Aydın, A., et al. (2007). Otizm Davranış Kontrol Listesinin (ABC) geçerlilik ve güvenilirliğinin incelenmesi. Çocuk ve Gençlik Ruh Sağlığı Dergisi, 14(1), 13–23.

    Google Scholar 

  • Youngstrom, E. A., Gracious, B. L., Danielson, C. K., et al. (2003). Toward an integration of parent and clinician report on the Young Mania Rating Scale. Journal Of Affective Disorders, 77, 179–190.

    Article  PubMed  Google Scholar 

Download references

Author Contributions

DS, SB, SA are involved in determining the aim and method of the research, and in the data collection, data analysis, reviewing the existing literature, and writing stages.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Saliha Baykal.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sapmaz, D., Baykal, S. & Akbaş, S. The Clinical Features of Comorbid Pediatric Bipolar Disorder in Children with Autism Spectrum Disorder. J Autism Dev Disord 48, 2800–2808 (2018). https://doi.org/10.1007/s10803-018-3541-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10803-018-3541-x

Keywords

Navigation