Differences in Neural Correlates of Speech Perception in 3 Month Olds at High and Low Risk for Autism Spectrum Disorder

  • Laura A. Edwards
  • Jennifer B. Wagner
  • Helen Tager-Flusberg
  • Charles A. Nelson
Original Paper

Abstract

In this study, we investigated neural precursors of language acquisition as potential endophenotypes of autism spectrum disorder (ASD) in 3-month-old infants at high and low familial ASD risk. Infants were imaged using functional near-infrared spectroscopy while they listened to auditory stimuli containing syllable repetitions; their neural responses were analyzed over left and right temporal regions. While female low risk infants showed initial neural activation that decreased over exposure to repetition-based stimuli, potentially indicating a habituation response to repetition in speech, female high risk infants showed no changes in neural activity over exposure. This finding may indicate a potential neural endophenotype of language development or ASD specific to females at risk for the disorder.

Keywords

Autism spectrum disorders Near infrared spectroscopy Speech processing Infancy Endophenotype Language 

Supplementary material

10803_2017_3222_MOESM1_ESM.docx (232 kb)
Supplementary material 1 (DOCX 231 KB)

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Laura A. Edwards
    • 1
    • 4
    • 5
  • Jennifer B. Wagner
    • 2
  • Helen Tager-Flusberg
    • 3
  • Charles A. Nelson
    • 4
    • 5
  1. 1.Marcus Autism CenterAtlantaUSA
  2. 2.College of Staten IslandNew YorkUSA
  3. 3.Boston UniversityBostonUSA
  4. 4.Boston Children’s HospitalHarvard UniversityBostonUSA
  5. 5.Harvard Graduate School of EducationCambridgeUSA

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