Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder
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We investigated heart rate (HR) in infants at 3, 6, 9, and 12 months of age, at high (HRA) and low (LRC) familial risk for ASD, to identify potential endophenotypes of ASD risk related to attentional responses. HR was extracted from functional near-infrared spectroscopy recordings while infants listened to speech stimuli. Longitudinal analysis revealed that HRA infants and males generally had lower baseline HR than LRC infants and females. HRA infants showed decreased HR responses to early trials over development, while LRC infants showed increased responses. These findings suggest altered developmental trajectories in physiological responses to speech stimuli over the first year of life, with HRA infants showing less social orienting over time.
KeywordsAutism spectrum disorders Heart rate Infancy Endophenotype Auditory processing
We are extremely grateful to the families for their invaluable contribution to the Infant Sibling Project. We would also like to acknowledge the Infant Sibling Project staff—Tara Augenstein, Lauren Baczewski, Leah Casner, Kristin Concannon, Frances Cooley, Morgan Crossman, Kerri Downing, Mary Kate Driscoll, Sharon Fox, Linnea Joffe-Nelson, Kristina Joas, Brandon Keehn, Jack Keller, Nina Leezenbaum, Vanessa Loukas, Rhiannon Luyster, Stephanie Marshall, Sarah Mumanachit, Anne Seery, Meagan Thompson, Vanessa Vogel-Farley, Jennifer Wagner, and Anne-Marie Zuluaga—for their assistance in data acquisition and helpful advice.
CAN, HTF conceived and designed the Infant Sibling Project. KLP, CAN designed the HR study. KLP, LAE analyzed data. KLP, LAE, CAN, HTF participated in the interpretation of the data. KLP, LAE drafted the manuscript. CAN, HTF critically revised the manuscript for important intellectual content. All authors read and approved the final manuscript.
This research was supported by National Institutes of Health Grant R01-DC010290 to Helen Tager-Flusberg and Charles A. Nelson and The Simons Foundation (137186) to Charles A. Nelson.
Compliance with Ethical Standards
Conflict of interest
Katherine L. Perdue, Laura A. Edwards, Helen Tager-Flusberg, and Charles A. Nelson declared that they have no conflict of interest.
All study procedures were monitored and approved by the Boston Children’s Hospital Institutional Review Board under IRB protocol X10-02-0083. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study. This article does not contain any studies with animals performed by any of the authors.
- Baio, J. (2014). Prevalence of autism spectrum disorder among children aged 8 years—Autism and developmental disabilities monitoring network, 11 sites, United States, 2010. Center for Disease Control and Prevention Surveillance Summaries, 63(2), 1–24.Google Scholar
- Bal, E., Harden, E., Lamb, D., Van Hecke, A. V., Denver, J. W., & Porges, S. W. (2010). Emotion recognition in children with autism spectrum disorders: relations to eye gaze and autonomic state. Journal of Autism and Developmental Disorders, 40(3), 358–370. doi: 10.1007/s10803-009-0884-3.CrossRefPubMedGoogle Scholar
- Daluwatte, C., Miles, J. H., Christ, S. E., Beversdorf, D. Q., Takahashi, T. N., & Yao, G. (2013). Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 43(8), 1910–1925. doi: 10.1007/s10803-012-1741-3.CrossRefPubMedPubMedCentralGoogle Scholar
- Kushki, A., Drumm, E., Pla Mobarak, M., Tanel, N., Dupuis, A., Chau, T., & Anagnostou, E. (2013). Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders. PloS One, 8(4), e59730–e59710. doi: 10.1371/journal.pone.0059730.CrossRefPubMedPubMedCentralGoogle Scholar
- Levine, T. P., Sheinkopf, S. J., Pescosolido, M., Rodino, A., Elia, G., & Lester, B. (2012). Physiologic arousal to social stress in children with autism spectrum disorders: A pilot study. Research in Autism Spectrum Disorders, 6(1), 177–183. doi: 10.1016/j.rasd.2011.04.003.CrossRefPubMedPubMedCentralGoogle Scholar
- Lord, C., Rutter, M., Dilavore, P., & Risi, S. (2008). ADOS: Autism diagnostic observation schedule. Boston: Hogrefe.Google Scholar
- Pierce, K., Marinero, S., Hazin, R., McKenna, B., Barnes, C. C., & Malige, A. (2016). Eye tracking reveals abnormal visual preference for geometric images as an early biomarker of an autism spectrum disorder subtype associated with increased symptom severity. Biological Psychiatry, 79(8), 657–666. doi: 10.1016/j.biopsych.2015.03.032.CrossRefPubMedGoogle Scholar
- Pinheiro, J., Bates, D., DebRoy, S., Sarkar, D., R Core Team. (2016). Linear and nonlinear mixed effects models [R package nlme version 3.1-128]. http://CRAN.R-project.org/package=nlme.
- Porges, S. W., Macellaio, M., Stanfill, S. D., McCue, K., Lewis, G. F., Harden, E. R., et al. (2013). Respiratory sinus arrhythmia and auditory processing in autism: modifiable deficits of an integrated social engagement system? International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, 88(3), 261–270. doi: 10.1016/j.ijpsycho.2012.11.009.CrossRefGoogle Scholar
- R Core Team. (2016). R: A Language and Environment for Statistical Computing. Vienna: R Core Team. https://www.R-project.org/.
- Rutter, M., Bailey, A., & Lord, C. (2003). The Social Communication Questionnaire. Torrance, CA: Western Psychological Services.Google Scholar
- Watson, L. R., Roberts, J. E., Baranek, G. T., Mandulak, K. C., & Dalton, J. C. (2012). Behavioral and physiological responses to child-directed speech of children with autism spectrum disorders or typical development. Journal of Autism and Developmental Disorders, 42(8), 1616–1629. doi: 10.1007/s10803-011-1401-z.CrossRefPubMedPubMedCentralGoogle Scholar