Brief Report: The ADOS Calibrated Severity Score Best Measures Autism Diagnostic Symptom Severity in Pre-School Children
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The severity of autism spectrum disorder (ASD) is often measured by co-occurring conditions, such as intellectual disability or language delay, rather than deficits in social interaction, and restricted interests and repetitive behaviors. The Autism Diagnostic Observation Schedule calibrated severity score (ADOS CSS) was created to facilitate comparison of the diagnostic features of ASD independent of related conditions over time. We examined the relationship between the ADOS CSS, ADOS total score, and clinician rated degree of impairment (DOI) in the Study to Explore Early Development. Like others, we confirmed that, among the measures we evaluated, the ADOS CSS was least influenced by developmental functioning and demographic factors and is therefore the best measure of core features of ASD in pre-school children.
KeywordsAutism Diagnostic Observation Schedule Autism spectrum disorder Calibrated severity score Symptom severity
This publication was supported by six cooperative agreements from the Centers for Disease Control and Prevention: Cooperative Agreement Number U10DD000180, Colorado Department of Public Health; Cooperative Agreement Number U10DD000181, Kaiser Foundation Research Institute (CA); Cooperative Agreement Number U10DD000182, University of Pennsylvania; Cooperative Agreement Number U10DD000183, Johns Hopkins University; Cooperative Agreement Number U10DD000184, University of North Carolina at Chapel Hill; and Cooperative Agreement Number U10DD000498, Michigan State University. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC or HRSA.
Study concept (Lisa Wiggins), study design and methods (all authors), statistical analysis (Brian Barger), statistical review and interpretation (all authors), manuscript preparation and/or review (all authors).
Compliance with Ethical Standards
Conflict of interest
The authors do not have any conflicts of interest to report.
All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Achenbach, T. (1992). Child Behavior Checklist. Burlington: Achenbach System of Empirically based Assessment.Google Scholar
- Cohen, J. (1988). Statistical power analysis for the behavioral sciences (2nd edn.). Hillsdale: Lawrence Earlbaum Associates.Google Scholar
- Levy, S. E., Giarelli, E., Lee, L. C., Schieve, L., Kirby, R., Cunniff, C., et al. (2010). Autism spectrum disorder and co-occurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States. Journal of Developmental and Behavioral Pediatrics, 31(4), 267–275.CrossRefPubMedGoogle Scholar
- Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism Diagnostic Observation Schedule. Los Angeles: Western Psychological Services.Google Scholar
- Lord, C., Rutter, M., & Le Couteur, A. L. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMedGoogle Scholar
- Mullen, E. (1995). Mullen Scales of Early Learning. San Antonio: Pearson.Google Scholar
- Rutter, M.A., Bailey, A. & Lord, C. (2003). The Social Communication Questionnaire. Los Angeles: Western Psycholgical Services.Google Scholar
- Schendel, D., DiGuiseppi, C., Croen, L., Fallin, D., Reed, P., Schieve, L., et al. (2012). The Study to Explore Early Development (SEED): A multi-site epidemiologic study of autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network. Journal of Autism and Developmental Disorders, 42, 2121–2140.CrossRefPubMedPubMedCentralGoogle Scholar
- Sparrow, S., Balla, D., & Cicchetti, D. (2005). Vineland Adaptive Behavior Scales, (2nd edn). San Antonio: Pearson.Google Scholar
- Wiggins, L. D., Reynolds, A., Rice, C., Moody, E. J., Bernal, P., Blaskey, L., Rosenberg, S. A., Lee, L.-C., & Levy, S. (2015). Using standardized diagnostic instruments to classify children with autism in the Study to Explore Early Development. Journal of Autism and Developmental Disorders, 45, 1271–1280.CrossRefPubMedPubMedCentralGoogle Scholar