Brief Report: Characteristics of preschool children with ASD vary by ascertainment
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Prospective studies of infant siblings of children diagnosed with autism spectrum disorder (ASD) provide a unique opportunity to characterize ASD as it unfolds. A critical question that remains unanswered is whether and how these children with ASD resemble other children identified from the community, including those with no family history. The purpose of this study was to compare clinical characteristics of children with ASD identified by each method (n = 86 per group), drawn from two Canadian longitudinal research cohorts. Children ascertained from a prospective cohort were less severely affected and included a larger proportion of girls, compared to the clinically referred sample. These results may have important implications for conclusions drawn from studies of high-risk and clinically referred cohorts.
KeywordsAutism spectrum disorder High-risk siblings Prospective Community referral Comparison
The authors would like to thank the research assistants at each site for their help with data collection and the parents and children who participated in our study. The study was funded by Canadian Institutes of Health Research (CIHR) and NeuroDevNet.
LRS made substantial contributions to conception and design of the paper, analyzed the data, and prepared the first draft of the paper, and approved the final draft. LZ, PS, SB, SG, JB, IMS, TV, NG, CR, ME contributed to the conception of the project, provided a critical review of the manuscript, and approved the final draft.
This study was funded by the Canadian Institutes of Health Research (CIHR) and NeuroDevNet.
Compliance with Ethical Standards
Conflict of interest
All of the authors declare that they have no conflicts of interest.
All of the procedures involving our human participants were performed in accordance with the ethical standards of the institutional boards at each institution and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individual participants (parents) prior to study onset.
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