Journal of Autism and Developmental Disorders

, Volume 47, Issue 5, pp 1391–1402 | Cite as

Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder

  • Johanna K. Lake
  • Danica Denton
  • Yona Lunsky
  • Amy  M. Shui
  • Jeremy Veenstra-VanderWeele
  • Evdokia Anagnostou
Original Paper

Abstract

This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2–11 (n = 4749) and those 12–17 (n = 401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems.

Keywords

Autism spectrum disorder Atypical antipsychotic medication Children 

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Johanna K. Lake
    • 1
    • 2
  • Danica Denton
    • 3
  • Yona Lunsky
    • 1
    • 2
  • Amy  M. Shui
    • 4
  • Jeremy Veenstra-VanderWeele
    • 5
    • 6
  • Evdokia Anagnostou
    • 7
    • 8
  1. 1.Underserved Populations Program Centre for Addiction and Mental HealthTorontoCanada
  2. 2.Department of PsychiatryUniversity of TorontoTorontoCanada
  3. 3.Department of PsychiatryPhoenix Children’s HospitalPhoenixUSA
  4. 4.Massachusetts General Hospital, Biostatistics CenterHarvard Medical SchoolBostonUSA
  5. 5.Department of PsychiatryColumbia UniversityNew YorkUSA
  6. 6.New York State Psychiatric InstituteNew YorkUSA
  7. 7.Holland Bloorview Research InstituteTorontoCanada
  8. 8.Department of PaediatricsUniversity of TorontoTorontoCanada

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