Brief Report: Reduced Temporal-Central EEG Alpha Coherence During Joint Attention Perception in Adolescents with Autism Spectrum Disorder
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Although prior studies have demonstrated reduced resting state EEG coherence in adults with autism spectrum disorder (ASD), no studies have explored the nature of EEG coherence during joint attention. We examined the EEG coherence of the joint attention network in adolescents with and without ASD during congruent and incongruent joint attention perception and an eyes-open resting condition. Across conditions, adolescents with ASD showed reduced right hemisphere temporal–central alpha coherence compared to typically developing adolescents. Greater right temporal–central alpha coherence during joint attention was positively associated with social cognitive performance in typical development but not in ASD. These results suggest that, in addition to a resting state, EEG coherence during joint attention perception is reduced in ASD.
KeywordsEEG coherence Joint attention Brain connectivity Cortical connectivity Joint attention network connectivity Neurocognitive features of joint attention in ASD Adolescents with ASD Adolescent autistic brain
We would like to acknowledge and thank Justin H. G. Williams for providing us with the video stimulus used in this study, Mark E. Pflieger of Source Signal Imaging for consultation on analyses, and the National Institutes of Health (Grant R01 NIMH 071273; Mundy and Henderson co-PIs) for their support. A version of this study was presented at the International Meeting for Autism Research in 2010.
This study was funded by NIMH Grant RO1 MH071273.
MJ was responsible for the final design the study, led the execution of the study, performed the statistical and EEG analyses, and drafted the manuscript; CM participated in the coordination of the study and helped to draft the manuscript; BD participated in the coordination of the study and helped to draft the manuscript; LN participated in the initial design of the study and helped to draft the manuscript; PM conceived the study, participated in the initial design of the study, and helped to draft the manuscript; HH participated in the interpretation of the data and helped to draft the manuscript.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent and assent was obtained from all individual participants included in the study.
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