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Journal of Autism and Developmental Disorders

, Volume 46, Issue 2, pp 523–533 | Cite as

Maternal Psychiatric Disorder and the Risk of Autism Spectrum Disorder or Intellectual Disability in Subsequent Offspring

  • Jenny FairthorneEmail author
  • Geoff Hammond
  • Jenny Bourke
  • Nick de Klerk
  • Helen Leonard
Original Paper

Abstract

Psychiatric disorders are more common in the mothers of children with autism spectrum disorder (ASD) or intellectual disability (ID) after the birth of their child. We aimed to assess the relationship between women’s psychiatric contacts and subsequent offspring with ASD/ID. We linked three Western Australian registers to investigate pre-existing maternal outpatient psychiatric contacts and the odds of ASD/ID in a subsequent child. Women with a previous outpatient psychiatric contact were more than twice as likely to have a child with ASD [OR 2.07 (95 % CI 1.7, 2.6)] or ID [OR 2.31 (2.1, 2.6)]. Further research exploring the effect on pregnancy outcomes of medications prescribed to women with psychiatric disorders is implicated.

Keywords

Autism Intellectual Psychiatric Mothers Pre-existing Prenatal medication 

Notes

Acknowledgments

The authors are grateful to the Disability Services Commission, the Telethon Kids Institute, the Western Australia Department of Education, the Catholic Education Office and the Association of Independent Schools of Western Australia for assistance with data collection for the IDEA database. This study was supported by Australian National Health and Medical Research Council (NHMRC) Program Grant #572742.

Author Contributions

All authors participated in the conception and planning of the study, Dr Fairthorne, Dr Hammond and Professor de Klerk provided statistical input to the methods and Dr Fairthorne performed all statistical calculations.Dr Fairthorne wrote the initial draft and all co-authors provided input on subsequent versions.

Compliance with Ethical Standards

Conflict of interest

None.

Supplementary material

10803_2015_2594_MOESM1_ESM.docx (26 kb)
Supplementary material 1 (DOCX 26 kb)

References

  1. American Psychiatric Association. (2013). The diagnostic and statistical manual of mental disorders: DSM 5. Arlington, VA: BookpointUS.CrossRefGoogle Scholar
  2. Australian Bureau of Statistics. (2008). Information paper: An introduction to socio-economic indexes for areas (SEIFA). http://www.abs.gov.au/ausstats/abs@.nsf/mf/2039.0.
  3. Bailey, D., Golden, R., Roberts, J., & Ford, A. (2007). Maternal depression and developmental disability: Research critique. Mental Retardation and Developmental Disabilities Research Reviews, 13(4), 321–329.CrossRefPubMedGoogle Scholar
  4. Bolton, P., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28(2), 385–395.CrossRefPubMedGoogle Scholar
  5. Carroll, L., & Owen, M. (2009). Genetic overlap between autism, schizophrenia and bipolar disorder. Genome Medicine, 1(10), 102.PubMedCentralCrossRefPubMedGoogle Scholar
  6. Centers for Disease Control and Prevention. (2014). Prevalence of Autism Spectrum Disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2010. Morbidity and Mortality Weekly Report, 63(2), 1–21.Google Scholar
  7. Christensen, J., Grønborg, T., Sørensen, M., Schendel, D., Parner, E., Pedersen, L., & Vestergaard, M. (2013). Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. Journal of the American Medical Association, 309(16), 1696–1703.PubMedCentralCrossRefPubMedGoogle Scholar
  8. Croen, L., Grether, J., Yoshida, C., Odouli, R., & Hendrick, V. (2011). Antidepressant use during pregnancy and childhood autism spectrum disorders. Archives of General Psychiatry, 68(11), 1104–1112.CrossRefPubMedGoogle Scholar
  9. Daniels, J., Forssen, U., Hultman, C., Cnattingius, S., Savitz, D., Feychting, M., & Sparen, P. (2008). Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics, 121(5), 1357–1362.CrossRefGoogle Scholar
  10. Davis, E., Fennoy, I., Laraque, D., Kanem, N., Brown, G., & Mitchell, J. (1992). Autism and developmental abnormalities in children with perinatal cocaine exposure. Journal of the National Medical Association, 84(4), 315.PubMedCentralPubMedGoogle Scholar
  11. Department of Health of Western Australia, G. o. W. A. (2015). Disability services. Retrieved May 14, 2015, from http://www.health.wa.gov.au/services/category.cfm?Topic_ID=12.
  12. Department of Health WA. (2011). What we collect and manage. Retrieved May 12, 2011, from http://www.health.wa.gov.au/healthdata/statewide/index.cfm.
  13. Eriksson, M., Westerlund, J., Anderlid, B., Gillberg, C., & Fernell, E. (2012). First-degree relatives of young children with autism spectrum disorders: Some gender aspects. Research in Developmental Disabilities, 33(5), 1642–1648. doi: 10.1016/j.ridd.2012.03.025.CrossRefPubMedGoogle Scholar
  14. Fairthorne, J., Jacoby, P., Bourke, J., de Klerk, N., & Leonard, H. (2015). Onset of maternal psychiatric disorders after the birth of a child with intellectual disability: A retrospective cohort study. Journal of Psychiatry Research, 61, 223–230. doi: 10.1016/j.jpsychires.2014.11.011.CrossRefGoogle Scholar
  15. Fairthorne, J., Langridge, A., Bourke, J., & Leonard, H. (2013). Pre-existing differences in mothers of children with autism spectrum disorder and/or intellectual disability: A review. In M. Fitzgerald (Ed.), Recent advances in autism spectrum disorders (Vol. 1, pp. 387–423). Rijeka: In Tech.Google Scholar
  16. Feero, W., Guttmacher, A., Mefford, H., Batshaw, M., & Hoffman, E. (2012). Genomics, intellectual disability, and autism. New England Journal of Medicine, 366(8), 733–743.CrossRefGoogle Scholar
  17. Garg, S., Lehtonen, A., Huson, S., Emsley, R., Trump, D., Evans, D., & Green, J. (2013). Autism and other psychiatric comorbidity in neurofibromatosis type 1: Evidence from a population-based study. Developmental Medicine and Child Neurology, 55(2), 139–145.CrossRefPubMedGoogle Scholar
  18. Green, S. (2003). What do you mean ‘What’s wrong with her?’: Stigma and the lives of families of children with disabilities. Social Science and Medicine, 57(8), 1361–1374.CrossRefPubMedGoogle Scholar
  19. Greenwood, C., Husted, J., Bomba, M., Hodgkinson, K., & Bassett, A. (2004). Elevated rates of schizophrenia in a familial sample with mental illness and intellectual disability. Journal of Intellectual Disability Research, 48(6), 531–539. doi: 10.1111/j.1365-2788.2004.00621.x.PubMedCentralCrossRefPubMedGoogle Scholar
  20. Griffith, M., Mann, J., & McDermott, S. (2011). The risk of intellectual disability in children born to mothers with preeclampsia or eclampsia with partial mediation by low birth weight. Hypertension in Pregnancy, 30(1), 108–115. doi: 10.3109/10641955.2010.507837.CrossRefPubMedGoogle Scholar
  21. Hoekstra, R., Happé, F., Baron-Cohen, S., & Ronald, A. (2009). Association between extreme autistic traits and intellectual disability: Insights from a general population twin study. The British Journal of Psychiatry, 195(6), 531–536.CrossRefPubMedGoogle Scholar
  22. Hultman, C., Sandin, S., Levine, S., Lichtenstein, P., & Reichenberg, A. (2011). Advancing paternal age and risk of autism: New evidence from a population-based study and a meta-analysis of epidemiological studies. Molecular Psychiatry, 16(12), 1203–1212.CrossRefPubMedGoogle Scholar
  23. Jokiranta, E., Brown, A., Heinimaa, M., Cheslack-Postava, K., Suominen, A., & Sourander, A. (2013). Parental psychiatric disorders and autism spectrum disorders. Psychiatry Research, 207(3), 203–211.PubMedCentralCrossRefPubMedGoogle Scholar
  24. Kogan, M., Strickland, B., Blumberg, S., Singh, G., Perrin, J., & Van Dyck, P. (2008). A national profile of the health care experiences and family impact of autism spectrum disorder among children in the United States, 2005–2006. Pediatrics, 122(6), e1149–e1158.CrossRefPubMedGoogle Scholar
  25. Lampi, K., Lehtonen, L., Tran, P., Suominen, A., Lehti, V., Banerjee, P., & Sourander, A. (2012). Risk of autism spectrum disorders in low birth weight and small for gestational age infants. Journal of Pediatrics, 161(5), 830–836. doi: 10.1016/j.jpeds.2012.04.058.PubMedCentralCrossRefPubMedGoogle Scholar
  26. Langridge, A., Glasson, E., Nassar, N., Jacoby, P., Pennell, C., Hagan, R., & Stanley, F. (2013). Maternal conditions and perinatal characteristics associated with autism spectrum disorder and intellectual disability. PLoS One, 8(1), e50963.PubMedCentralCrossRefPubMedGoogle Scholar
  27. Larsson, H., Eaton, W., Madsen, K., Vestergaard, M., Olesen, A., Agerbo, E., & Mortensen, P. (2005). Risk factors for autism: Perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), 916–925.CrossRefPubMedGoogle Scholar
  28. Lauritsen, M., Pedersen, C., & Mortensen, P. (2005). Effects of familial risk factors and place of birth on the risk of autism: A nationwide register-based study. Journal of Child Psychology and Psychiatry, 46(9), 963–971.CrossRefPubMedGoogle Scholar
  29. Lawrence, D., Kisely, S., & Pais, J. (2010). The epidemiology of excess mortality in people with mental illness. Canadian Journal of Psychiatry, 55(12), 752–760.PubMedGoogle Scholar
  30. Leonard, H. (2004). Inaugural report of the IDEA database: Intellectual disability in Western Australia. Perth: Telethon Institute for Child Health Research.Google Scholar
  31. Leonard, H., Glasson, E., Nassar, N., Whitehouse, A., Bebbington, A., Bourke, J., & Stanley, F. (2011). Autism and intellectual disability are differentially related to sociodemographic background at birth. PLoS One, 6(3), e17875.PubMedCentralCrossRefPubMedGoogle Scholar
  32. Leonard, H., Petterson, B., Bower, C., & Sanders, R. (2002). Prevalence of intellectual disability in Western Australia. Paediatric and Perinatal Epidemiology, 17(1), 58–67.CrossRefGoogle Scholar
  33. Maimburg, R., & Væth, M. (2006). Perinatal risk factors and infantile autism. Acta Psychiatrica Scandinavica, 114(4), 257–264. doi: 10.1111/j.1600-0447.2006.00805.x.CrossRefPubMedGoogle Scholar
  34. Matson, J., & Shoemaker, M. (2009). Intellectual disability and its relationship to autism spectrum disorders. Research in Developmental Disabilities, 30(6), 1107–1114.CrossRefPubMedGoogle Scholar
  35. McConnell, D., Mayes, R., & Llewellyn, G. (2008). Women with intellectual disability at risk of adverse pregnancy and birth outcomes. Journal of Intellectual Disability Research, 52(6), 529–535. doi: 10.1111/j.1365-2788.2008.01061.x.CrossRefPubMedGoogle Scholar
  36. McPartland, J., & Klin, A. (2006). Asperger’s syndrome. Adolescent Medicine Clinics, 17(3), 771–788.PubMedGoogle Scholar
  37. Morgan, V., Croft, M., Valuri, G., Zubrick, S., Bower, C., McNeil, T., & Jablensky, A. (2012). Intellectual disability and other neuropsychiatric outcomes in high-risk children of mothers with schizophrenia, bipolar disorder and unipolar major depression. British Journal of Psychiatry, 205(4), 282–289.CrossRefGoogle Scholar
  38. Nassar, N., Dixon, G., Bourke, J., Bower, C., Glasson, E., De Klerk, N., & Leonard, H. (2009). Autism spectrum disorders in young children: Effect of changes in diagnostic practices. International Journal of Epidemiology, 38(5), 1245–1254.CrossRefPubMedGoogle Scholar
  39. Newschaffer, C., Croen, L., Daniels, J., Giarelli, E., Grether, J., Levy, S., & Reaven, J. (2007). The epidemiology of autism spectrum disorders. Annual Review of Public Health, 28(21), 235–258.CrossRefPubMedGoogle Scholar
  40. O’Donnell, M., Anderson, D., Morgan, V., Nassar, N., Leonard, H., & Stanley, F. (2013). Trends in pre-existing mental health disorders among parents of infants born in Western Australia from 1990 to 2005. Medical Journal of Australia, 198(9), 485–488.CrossRefPubMedGoogle Scholar
  41. Olsson, M., & Hwang, C. (2001). Depression in mothers and fathers of children with intellectual disability. Journal of Intellectual Disability Research, 45(6), 535–543.CrossRefPubMedGoogle Scholar
  42. Pal, L., Bevilacqua, K., & Santoro, N. (2010). Chronic psychosocial stressors are detrimental to ovarian reserve: A study of infertile women. Journal of Psychosomatic Obstetrics and Gynecology, 31(3), 130–139.CrossRefPubMedGoogle Scholar
  43. Petterson, B., Leonard, H., Bourke, J., Sanders, R., Chalmers, R., Jacoby, P., & Bower, C. (2005). IDEA (Intellectual Disability Exploring Answers): A population-based database for intellectual disability in Western Australia. Annals of Human Biology, 32(2), 237–243.CrossRefPubMedGoogle Scholar
  44. Ropers, H., & Hamel, B. (2005). X-linked mental retardation. Nature Reviews Genetics, 6(1), 46–57.CrossRefPubMedGoogle Scholar
  45. Sandin, S., Schendel, D., Magnusson, P., Hultman, C., Surén, P., Susser, E., et al. (2015). Autism risk associated with parental age and with increasing difference in age between the parents. Molecular Psychiatry. doi: 10.1038/mp.2015.70.PubMedGoogle Scholar
  46. Sullivan, P., Magnusson, C., Reichenberg, A., Boman, M., Dalman, C., Davidson, M., & Långström, N. (2012). Family history of schizophrenia and bipolar disorder as risk factors for autism. Archives of General Psychiatry, 2, 1–5.Google Scholar
  47. Totsika, V., Hastings, R., Emerson, E., Lancaster, G., & Berridge, D. (2011). A population-based investigation of behavioural and emotional problems and maternal mental health: Associations with autism spectrum disorder and intellectual disability. Journal of Child Psychology and Psychiatry, 52(1), 91–99.CrossRefPubMedGoogle Scholar
  48. Wiggs, L., & Stores, G. (1996). Severe sleep disturbance and daytime challenging behaviour in children with severe learning disabilities. Journal of Intellectual Disability Research, 40(6), 518–528.CrossRefPubMedGoogle Scholar
  49. Woodward, M. (2005). Epidemiology: Study design and analysis (2nd ed.). Boca Raton, US: Chapman and Hall.Google Scholar
  50. Yeargin-Allsopp, M., Murphy, C., Cordero, J., Decouffle, P., & Hollowell, J. (1997). Reported biomedical causes and associated medical conditions for mental retardation among 10 year old children, metropolitan Atlanta, 1985 to 1987. Developmental Medicine and Child Neurology, 39, 142–149.CrossRefPubMedGoogle Scholar

Copyright information

© Her Majesty the Queen in Right of Australia 2015

Authors and Affiliations

  1. 1.Telethon Kids InstituteUniversity of Western AustraliaPerthAustralia
  2. 2.Health Department of Western AustraliaPerthAustralia

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