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Journal of Autism and Developmental Disorders

, Volume 45, Issue 11, pp 3668–3679 | Cite as

Autism Symptoms Across Adulthood in Men with Fragile X Syndrome: A Cross-Sectional Analysis

  • Sigan L. Hartley
  • Anne C. Wheeler
  • Marsha R. Mailick
  • Melissa Raspa
  • Iulia Mihaila
  • Ellen Bishop
  • Donald B. Bailey
Original Paper

Abstract

A cross-sectional analysis was used to examine age-related differences in ASD symptoms and corresponding differences in disruptive behavior and social skills in 281 adult men with fragile X syndrome. Four age groups were created: 18–21, 22–29, 30–39, and 40–49 years. The 18–21 year-old group was reported to have more impairments in verbal communication than the 22–29 year-old group and more restricted and repetitive behaviors than the 40–49 year-old group. There was not an age-group difference in the percentage of men who met criteria for an ASD diagnosis based on respondent-reported, current symptoms. There was a trend for an age-related difference in disruptive behavior. Findings add to understanding of the developmental trajectory of ASD symptoms in adulthood.

Keywords

Fragile X syndrome Autism DSM Adult Aging 

Notes

Acknowledgments

This study was funded in part by the Centers for Disease Control and Prevention (CDC), National Center on Birth Defects and Developmental Disabilities (NCBDD) under Cooperative Agreement U01DD000231 to the Association of University Centers on Disabilities (AUCD), project RTOI 2010-99-01. This study was also funded in part by the National Institute of Child Health and Human Development (NICHD; P30 HD03352 to M. Mailick). The findings and conclusions in this article are those of the authors and do not necessarily represent the views of CDC, AUCD, or NICHD. We thank our team of collaborators and the families who participated in this survey.

References

  1. American Psychiatric Association (APA). (2013). Diagnostic and statistical manual of mental disorders (5th ed., Text Rev., DSM-5). Washington, DC: American Psychiatric Association.Google Scholar
  2. Bailey, D. B, Jr, Hatton, D. D., Skinner, M., & Mesibov, G. B. (2001). Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome. Journal of Autism and Developmental Disorders, 3, 165–174.CrossRefGoogle Scholar
  3. Bailey, D. B, Jr, Raspa, M., Holiday, D., Bishop, E., & Olmsted, M. (2009). Functional skills of individuals with fragile X syndrome: A lifespan cross-sectional analysis. American Journal on Intellectual and Developmental Disabilities, 114, 289–303.CrossRefPubMedGoogle Scholar
  4. Bailey, D. B., Raspa, M., Olmsted, M., & Holiday, D. B. (2008). Co-occurring conditions associated with FMR1 Gene variations. American Journal of Medical Genetics, Part A, 146, 2060–2069.CrossRefGoogle Scholar
  5. Constantino, J. N., & Gruber, C. P. (2005). Social responsiveness scale. Los Angeles: Western Psychological Services.Google Scholar
  6. Cornish, K., Turk, J., & Hagerman, R. (2008). The fragile X continuum: New advances and perspectives. Journal of Intellectual Disability Research, 52, 469–482.CrossRefPubMedGoogle Scholar
  7. Crawford, D. C., Acuna, J. M., & Sherman, S. L. (2001). FMR1 and the fragile X syndrome: Human genome epidemiology review. Genetics in Medicine, 3, 359–371.PubMedCentralCrossRefPubMedGoogle Scholar
  8. Demark, J. L., Feldman, M. A., & Holden, J. J. A. (2003). Behavioral relationship between autism and fragile X syndrome. American Journal on Mental Retardation, 108, 314–326.CrossRefPubMedGoogle Scholar
  9. Fecteau, S., Mottron, L., Berthiaume, C., & Burack, J. A. (2003). Developmental changes of autistic symptoms. Autism, 7, 255–268.CrossRefPubMedGoogle Scholar
  10. Hagerman, R. J. (2002). The physical and behavioral phenotype. In P. J. Hagerman (Ed.), Fragile X syndrome: Diagnosis, treatment, and research. Baltimore: The Johns Hopkins University Press.CrossRefGoogle Scholar
  11. Hagerman, R. J., & Hagerman, P. J. (2002). The fragile x premutation: Into the phenotypic fold. Current Opinions in Genetic Development, 12, 278–283.CrossRefGoogle Scholar
  12. Hagerman, R., Jackson, A. W., Levitas, A., Rimland, B., & Braden, M. (1986). An analysis of autism in fifty males with the fragile X syndrome. American Journal of Medical Genetics, 23, 359–374. doi: 10.1002/ajmg.1320230128.CrossRefPubMedGoogle Scholar
  13. Hartley, S. L., Seltzer, M. M., Raspa, M., Olmsted, M. G., Bishop, E. E., & Bailey, D. B. (2011). Exploring the adult life of men and women with fragile X syndrome: Results from a national survey. American Journal on Intellectual and Developmental Disabilities, 116, 16–35.PubMedCentralCrossRefPubMedGoogle Scholar
  14. Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B, Jr, Roberts, J., et al. (2006). Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics Part A, 140, 1804–1813.CrossRefGoogle Scholar
  15. Homes, N., Shah, A., & Wing, L. (1982). The disability assessment schedule: A brief screening device for use with the mentally retarded. Psychological Medicine, 12, 879–890. doi: 10.1017/S003329170049175.CrossRefGoogle Scholar
  16. Kaufmann, W. E., Cortell, R., Kau, A., Bukelis, I., Tierney, E., Gray, R., et al. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics, Part A, 129, 225–234.CrossRefGoogle Scholar
  17. Kaufmann, W. E., & Reiss, A. L. (1999). Molecular and cellular genetics of fragile X syndrome. American Journal of Medical Genetics, 88, 11–24.CrossRefPubMedGoogle Scholar
  18. Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMedGoogle Scholar
  19. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview—Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.CrossRefPubMedGoogle Scholar
  20. Maenner, M. J., Rice, C. E., Arneson, C. L., Cunniff, C., Schieve, L. A., Carpenter, L. A., et al. (2014). Potential impact of DSM-5 criteria on autism spectrum disorder prevalence estimates. Journal of the Medical Association Psychiatry. doi: 10.1001/jamapsychiatry.2013.3893.Google Scholar
  21. McDuffie, A., Abbeduto, L., Lewis, P., Kover, S., Kim, J. S., Weber, A., & Brown, W. T. (2010). Autism spectrum disorder in children and adolescents with fragile X syndrome: Within-syndrome differences and age-related changes. American Journal on Intellectual and Developmental Disabilities, 115, 307–326.Google Scholar
  22. McDuffie, A., Kover, S. T., Abbeduto, L., Lewis, P., & Brown, W. T. (2012). Profiles of receptive and expressive language in males with comorbid fragile X syndrome and autism. American Journal on Intellectual and Developmental Disabilities, 117, 18–32.PubMedCentralCrossRefPubMedGoogle Scholar
  23. Rogers, S. J., Wehner, E., & Hagerman, R. J. (2001). The behavioral phenotype in fragile x: Symptoms of autism in very young children with fragile x syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioral Pediatrics, 22, 409–417.CrossRefPubMedGoogle Scholar
  24. Rutter, M., Bailey, A., & Lord, C. (2001). Social communication questionnaire. Western Psychological Services: Los Angeles.Google Scholar
  25. Sabaratnam, M., Murthy, N. V., Wijeratne, A., Buckingham, A., & Payne, S. (2003). Autistic-like behaviour profile and psychiatric morbidity in fragile X Syndrome: A prospective ten-year follow-up study. European Child and Adolescent Psychiatry, 12, 172–177.CrossRefPubMedGoogle Scholar
  26. Schopler, E., Reicher, R., & Renner, B. (1988). The childhood autism rating scale (CARS). Los Angeles: Western Psychological Services.Google Scholar
  27. Seltzer, M. M., Krauss, M. W., Orsmond, G. I., & Vestal, C. (2000). Families of adolescents and adults with autism: Uncharted territory. In L. M. Glidden (Ed.), International review of research on mental retardation (Vol. 23, pp. 267–294). San Diego, CA: Academic Press.Google Scholar
  28. Shattuck, P. T., Seltzer, M. M., Greenberg, J. S., Orsmond, G. I., Bolt, D., Kring, S., et al. (2007). Change in autism symptoms and maladaptive behaviors in adolescents and adults with an autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 1735–1747. doi: 10.1007/s110803-006-0307-7.PubMedCentralCrossRefPubMedGoogle Scholar
  29. Smith, L. E., Barker, E. T., Seltzer, M. M., Abbeduto, L., & Greenberg, J. S. (2012a). Behavioral phenotype of Fragile X syndrome in adolescence and adulthood. American Journal of Intellectual and Developmental Disability, 117, 1–17. doi: 10.1352/1944-7558-117.1.1.CrossRefGoogle Scholar
  30. Smith, L. E., Maenner, M., & Seltzer, M. M. (2012b). Developmental trajectories in adolescents and adults with autism. The case of daily living skills. Journal of the American Academic of Child and Adolescent Psychiatry, 2159B, 589–597.Google Scholar
  31. Turk, J., & Graham, P. (1997). Fragile X syndrome, autism, and autistic features. Autism, 1, 175–197.CrossRefGoogle Scholar
  32. Volkmar, F., Chawarska, K., & Klin, A. (2005). Autism in infancy and early childhood. Annual Review of Psychology, 56, 15–36.CrossRefGoogle Scholar
  33. Wheeler, A. C., Mussey, J., Villagomez, A., Bishop, E., Raspa, M., Edwards, A., Bodfish, J., Bann, C., & Bailey, D. B. (2015). DSM-5 changes and the prevalence of parent-reported autsim spectrum disorders in fragile X syndrome. Journal of Autism and Developmental Disorders, 45, 816–829.Google Scholar
  34. Wing, L. (1980). The MRC handicaps, behaviour, & skills (HBS) schedule. Acta Psychiatrica Scandinavica, 62, 241–248. doi: 10.111/j.1600-0447.1980.tb07696.x.CrossRefGoogle Scholar
  35. Woodman, A. C., Smith, L. E., Greenberg, J. S., & Mailick, M. R. (2014). Change in autism symptoms and maladaptive behaviors in adolescence and adulthood: The role of positive family processes. Journal of Autism and Developmental Disorder, 45, 111–126.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Sigan L. Hartley
    • 1
  • Anne C. Wheeler
    • 2
  • Marsha R. Mailick
    • 3
  • Melissa Raspa
    • 2
  • Iulia Mihaila
    • 4
  • Ellen Bishop
    • 2
  • Donald B. Bailey
    • 2
  1. 1.Human Development and Family Studies and Waisman CenterUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.RTI InternationalResearch Triangle ParkUSA
  3. 3.Waisman CenterUniversity of Wisconsin-MadisonMadisonUSA
  4. 4.Human Development and Family StudiesUniversity of Wisconsin-MadisonMadisonUSA

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