Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED)
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This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses.
KeywordsAutism Etiology Symptoms Phenotype Study to Explore Early Development
We would like to thank Aimee Alexander for her assistance with data cleaning and the SEED principal investigators, co-principal investigators, project coordinators, project staff, and children and families who participated in this research. This publication was supported by six cooperative agreements from the Centers for Disease Control and Prevention: Cooperative Agreement Number U10DD000180, Colorado Department of Public Health; Cooperative Agreement Number U10DD000181, Kaiser Foundation Research Institute (CA); Cooperative Agreement Number U10DD000182, University of Pennsylvania; Cooperative Agreement Number U10DD000183, Johns Hopkins University; Cooperative Agreement Number U10DD000184, University of North Carolina at Chapel Hill; and Cooperative Agreement Number U10DD000498, Michigan State University. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
- Achenbach, T. (1992). Child behavior checklist. Burlington, VT: Achenbach System of Empirically based Assessment.Google Scholar
- American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Arlington, VA: American Psychiatric Publishing.Google Scholar
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.Google Scholar
- Centers for Disease Control and Prevention. (2014). Prevalence of autism spectrum disorders among children 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveillance Summaries, 63(SS02), 1–21.Google Scholar
- Constantino, J. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services.Google Scholar
- Department of Health and Human Services Interagency Autism Coordinating Committee website: http://iacc.hhs.gov/strategic-plan/2013/index.shtml.
- Interagency Autism Coordinating Committee (IACC). (2014). IACC strategic plan for autism spectrum disorder (ASD) research—2013 Update. April 2014. Retrieved from the US.Google Scholar
- Levy, S. E., Giarelli, E., Lee, L. C., Schieve, L., Kirby, R., Cunniff, C., et al. (2010). Autism spectrum disorder and co-occurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States. Journal of Developmental and Behavioral Pediatrics, 31(4), 267–275.CrossRefPubMedGoogle Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). the autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMedGoogle Scholar
- Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule. Los Angeles, CA: Western Psychological Services.Google Scholar
- Lord, C., Rutter, M., & Le Couteur, A. L. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24(5), 659–685.CrossRefPubMedGoogle Scholar
- Mullen, E. (1995). Mullen scales of early learning. San Antonio, TX: Pearson.Google Scholar
- Rutter, M. A., Bailey, A., & Lord, C. (2003). The social communication questionnaire. Los Angeles, CA: Western Psycholgical Services.Google Scholar
- Schendel, D., DiGuiseppi, C., Croen, L., Fallin, D., Reed, P., Schieve, L., et al. (2012). The study to explore early development (SEED): A multi-site epidemiologic study of autism by the centers for autism and developmental disabilities research and epidemiology (CADDRE) network. Journal of Autism and Developmental Disorders, 42, 2121–2140.PubMedCentralCrossRefPubMedGoogle Scholar
- Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(921), 929.Google Scholar
- Sparrow, S., Balla, D., & Cicchetti, D. (2005). Vineland adaptive behavior scales (2nd ed.). San Antonio, TX: Pearson.Google Scholar
- van der Meer, J. M., Oerlemans, A. M., van Steijn, D. J., Lappenschaar, M. G., de Sonneville, L. M., Buitelaar, J. K., & Rommelse, N. N. (2012). Are autism spectrum disorder and attention deficit hyperactivity disorder different manifestations of one overarching disorder? Cognitive and symptom evidence from a clinical and population-based sample. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 1160–1172.CrossRefPubMedGoogle Scholar
- Visser, S. N., Bitsko, R. H., Danielson, M. L., & Perou, R. (2010). Increasing prevalence of parent-reported attention deficit hyperactivity disorder among children—United States, 2003 and 2007. MMWR Surveillance Summaries, 59, 1439–1443.Google Scholar
- Walker, C. K., Krakowiak, P., Baker, A., Hansen, R., Ozonoff, S., & Hertz-Picciotto, I. (2014). Preecalmpsia, placental insufficiency, and autism spectrum disorder or developmental delay. JAMA Pediatrics. Advance on-line publication. doi: 10.1001/jamapediatrics.2014.2645.
- Wiggins, L. D., Reynolds, A., Rice, C., Moody, E. J., Bernal, P., Blaskey, L., et al. (2015). Using standardized diagnostic instruments to classify children with autism in the study to explore early development. Journal of Autism and Developmental Disorders, 45, 1271–1280.PubMedCentralCrossRefPubMedGoogle Scholar