The Relationship Between Autistic Symptomatology and Independent Living Skills in Adolescents and Young Adults with Fragile X Syndrome
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Few studies have examined the relationship between autistic symptomatology and competence in independent living skills in adolescents and young adults with fragile X syndrome (FXS). In this study, 70 individuals with FXS, aged 15–25 years, and 35 matched controls were administered direct measures of independent living skills and autistic symptomatology. Results showed that higher levels of autistic symptomatology were associated with lower levels of competence in independent living skills in individuals with FXS, but not in controls. These data indicated that the relationship between autistic symptomatology and independent living skills was syndrome-specific. Early intervention strategies that address autistic symptomatology are sorely needed to improve functional outcomes in this population.
KeywordsFragile X syndrome Functional skills Independent living skills Autistic symptomatology
This study was supported by Grant Numbers MH50047 (PI Allan Reiss) and K08MH081998 (PI Scott Hall) from the National Institute of Mental Health, a gift from the Canel Family, and the Fonds de Recherche Société et Culture Québec (Postdoctoral Grant to Eve-Marie Quintin).
- Cornish, K., Cole, V., Longhi, E., Karmiloff-Smith, A., & Scerif, G. (2012). Does attention constrain developmental trajectories in fragile X syndrome? A 3-year prospective longitudinal study. American Journal on Intellectual and Developmental Disabilities, 117(2), 103–120.CrossRefPubMedGoogle Scholar
- Hartley, S. L., Seltzer, M. M., Raspa, M., Olmstead, M., Bishop, E., & Bailey, D. B. (2011). Exploring the adult life of men and women with fragile X syndrome: Results from a national survey. American Journal on Intellectual and Developmental Disabilities, 116(1), 16–35.CrossRefPubMedCentralPubMedGoogle Scholar
- Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B, Jr, Roberts, J., & Mirrett, P. (2006). Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics. Part A, 140A(17), 1804–1813.CrossRefPubMedGoogle Scholar
- Loeb, P. A. (1996). Independent living scales manual. San Antonio, TX: Psychological Corporation.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.CrossRefPubMedGoogle Scholar
- McDuffie, A., Abbeduto, L., Lewis, P., Kover, S., Kim, J. S., Weber, A., et al. (2010). Autism spectrum disorder in children and adolescents with fragile X syndrome: Within-syndrome differences and age-related changes. American Journal on Intellectual and Developmental Disabilities, 115(4), 307–326.CrossRefPubMedCentralPubMedGoogle Scholar
- Reuben, D. B., Valle, L. A., Hays, R. D., & Siu, A. L. (1995). Measuring physical function in community-dwelling older persons: a comparison of self-administered, interviewer-administered, and performance-based measures. Journal of the American Geriatrics Society, 43(1), 17–23.CrossRefPubMedGoogle Scholar
- Rogers, S. J., Wehner, D. E., & Hagerman, R. (2001). The behavioral phenotype in fragile X: Symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. Journal of Developmental and Behavioral Pediatrics, 22(6), 409–417.CrossRefPubMedGoogle Scholar
- Wechsler, D. (1991). Wechsler intelligence scale for children (3rd ed.). San Antonio, TX: The Psychological Corporation.Google Scholar
- Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: The Psychological Corporation.Google Scholar
- Wolff, J. J., Bodfish, J. W., Hazlett, H. C., Lightbody, A. A., Reiss, A. L., & Piven, J. (2012). Evidence of a distinct behavioral phenotype in young boys with fragile X syndrome and autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51(12), 1324–1332.CrossRefPubMedCentralPubMedGoogle Scholar