Autism Spectrum Disorder Risk Factors and Autistic Traits in Gender Dysphoric Children
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Gender dysphoria (GD) and autism spectrum disorder (ASD) are associated. In 49 GD children (40 natal males), we examined ASD risk factors (i.e., birth weight, parental age, sibling sex ratio) in relation to autistic traits. Data were gathered on autistic traits, birth weight, parents’ ages at birth, sibling sex ratio, gender nonconformity, age, maternal depression, general behavioral and emotional problems, and IQ. High birth weight was associated with both high gender nonconformity and autistic traits among GD children. Developmental processes associated with high birth weight are, therefore, likely to underlie the GD–ASD link either directly or indirectly. The present study is the first to provide quantitative data bearing on possible mechanisms that lead GD and ASD to co-occur.
KeywordsGender dysphoria Autism spectrum disorder Birth weight Parental age Sibling sex ratio
D.P.V. was supported by a Canadian Institutes of Health Research Postdoctoral Fellowship. We thank two anonymous reviewers for comments on an earlier version of this article.
- Achenbach, T. M. (1991). Manual for the child behavior checklist/4-18 and 1991 profile. Burlington, VT: University of Vermont Department of Psychiatry.Google Scholar
- Alanko, K., Santtila, P., Harlaar, N., Witting, K., Varjoen, M., Jern, P., et al. (2010). Common genetic effects of gender atypical behavior in childhood and sexual orientation in adulthood: A study of Finnish twins. Archives of Sexual Behavior, 39, 81–92. doi: 10.1007/s10508-008-9457-3.CrossRefPubMedGoogle Scholar
- Alley, C. S., Gillberg, C., & Wilson, P. (2014). Neurobiological abnormalities in the first few years of life in individuals later diagnosed with autism spectrum disorder: A review of recent data. Behavioural Neurology. doi: 10.1155/2014/210780.
- Bennett, T., Boyle, M., Georgiades, K., Georgiades, S., Thompson, A., Duku, E., et al. (2012). Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors. Journal of Child Psychology and Psychiatry, 53, 89–96. doi: 10.1111/j.1469-7610.2011.02451.x.CrossRefPubMedGoogle Scholar
- Constantino, J. N., & Gruber, C. P. (2005). Social responsiveness scale. Los Angeles: Western Psychological Services.Google Scholar
- de Vries, A. L. C., Noens, I. L., Cohen-Kettenis, P. T., van Berckelaer-Onnes, I. A., & Doreleifers, T. A. (2010). Autism spectrum disorders in gender dysphoric children and adolescents. Journal of Autism and Developmental Disorders, 40, 930–936. doi: 10.1007/s10803-010-0935-9.CrossRefPubMedCentralPubMedGoogle Scholar
- Derogatis, L. R. (1994). Symptom checklist-90-R. Minneapolis: National Computer Systems Inc.Google Scholar
- Haugen, M., Brantsæter, A. L., Winkvist, A., Lissner, L., Alexander, J., Oftedal, B., et al. (2014). Associations of pre-pregnancy body mass index and gestational weight gain with pregnancy outcome and postpartum weight retention: A prospective observational cohort study. BMC Pregnancy and Childbirth, 14, 201. doi: 10.1186/1471-2393-14-201.CrossRefPubMedCentralPubMedGoogle Scholar
- Kirchengast, S., & Hartmann, B. (2013). Maternal obesity affects newborn somatometrices and vital parameters in a gender typical manner—Evidence for the male disadvantage hypothesis? Collegium Antropologicum, 4, 1057–1063.Google Scholar
- Lundström, S., Haworth, C. M. A., Carlström, E., Gillberg, C., Mill, J., Rastam, M., et al. (2010). Trajectories leading to autism spectrum disorders are affected by paternal age: Findings from two nationally representative twin studies. Journal of Child Psychology and Psychiatry, 51, 580–586. doi: 10.1111/j.1469-7610.2010.02223.x.CrossRefGoogle Scholar
- Sandin, S., Hultman, C. M., Kolevzon, A., Gross, R., MacCabe, J. H., & Reichenberg, A. (2012). Advancing maternal age is associated with increasing risk for autism: A review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 477–486. doi: 10.1016/j.jaac.2012.02.018.CrossRefPubMedGoogle Scholar
- VanderLaan, D. P., & Zucker, K. J. (in press). Gender dysphoria in children and adolescents. In M. H. Ebert, J. F. Leckman, & I. Petrakis (Eds.), Current diagnosis and treatment psychiatry 3rd edition. California: McGraw-Hill.Google Scholar
- Wechsler, D. (2003). WISC-IV technical and interpretive manual. San Antonio, TX: Psychological Corporation.Google Scholar
- Zucker, K. J., Bradley, S. J., Kuksis, M., Pecore, K., Birkenfeld-Adams, A., Doering, R. W., et al. (1999). Gender constancy judgements in children with gender identity disorder: Evidence for a developmental lag. Archives of Sexual Behavior, 28, 475–502. doi: 10.1023/A:1018713115866.CrossRefPubMedGoogle Scholar
- Zucker, K. J., Wood, H., & VanderLaan, D. P. (2014). Models of psychopathology in children and adolescents with gender dysphoria. In B. P. C. Kreukels, T. D. Steensma, & A. L. C. de Vries (Eds.), Gender dysphoria and disorders of sex development: Progress in care and knowledge (pp. 171–192). New York: Springer.CrossRefGoogle Scholar