Evidence for Diminished Multisensory Integration in Autism Spectrum Disorders
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Individuals with autism spectrum disorders (ASD) exhibit alterations in sensory processing, including changes in the integration of information across the different sensory modalities. In the current study, we used the sound-induced flash illusion to assess multisensory integration in children with ASD and typically-developing (TD) controls. Thirty-one children with ASD and 31 age and IQ matched TD children (average age = 12 years) were presented with simple visual (i.e., flash) and auditory (i.e., beep) stimuli of varying number. In illusory conditions, a single flash was presented with 2–4 beeps. In TD children, these conditions generally result in the perception of multiple flashes, implying a perceptual fusion across vision and audition. In the present study, children with ASD were significantly less likely to perceive the illusion relative to TD controls, suggesting that multisensory integration and cross-modal binding may be weaker in some children with ASD. These results are discussed in the context of previous findings for multisensory integration in ASD and future directions for research.
KeywordsAutism spectrum disorders Sensory processing Audiovisual Multisensory integration Audition Vision
Funding for this work was provided by a Banting Postdoctoral Fellowship, National Institutes of Health Grant F32 DC011993, Multisensory Integration and Temporal Processing in ASD, a Grant from the Vanderbilt Institute for Clinical and Translational Research, VICTR VR5807.1, Development and Modulation of Multisensory Integration, National Institutes of Health Grant R34 DC010927, Evaluation of Sensory Integration Treatment in ASD, a Vanderbilt Kennedy Center MARI/Hobbs Award, the Vanderbilt Brain Institute, and the Vanderbilt University Kennedy Center. We also acknowledge the help of Walter Lee and Zachary Barnett for technical assistance, and Magali Segers for clinical input.
- Altieri, N., Stevenson, R. A., Wallace, M. T., & Wenger, M. J. (2013). Learning to associate auditory and visual stimuli: Behavioral and neural mechanisms. Brain Topography. doi: 10.1007/s10548-013-0333-7.
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders-IV-TR. Washington, DC: APA.Google Scholar
- American Psychiatric Association, & American Psychiatric Association DSM-5 Task Force. (2013). Diagnostic and statistical manual of mental disorders: DSM-5 (5th ed.). Arlington, VA: American Psychiatric Association.Google Scholar
- Bebko, J. M., Weiss, J. A., Demark, J. L., & Gomez, P. (2006). Discrimination of temporal synchrony in intermodal events by children with autism and children with developmental disabilities without autism. Journal of Child Psychology and Psychiatry, 47(1), 88–98. doi: 10.1111/j.1469-7610.2005.01443.x.PubMedCrossRefGoogle Scholar
- Calvert, G. A., & Thesen, T. (2004). Multisensory integration: Methodological approaches and emerging principles in the human brain. Journal of Physiology—Paris, 98(1–3), 191–205.Google Scholar
- Foss-Feig, J. H., Kwakye, L. D., Cascio, C. J., Burnette, C. P., Kadivar, H., Stone, W. L., et al. (2010). An extended multisensory temporal binding window in autism spectrum disorders. Experimental Brain Research, 203(2), 381–389. doi: 10.1007/s00221-010-2240-4.PubMedCentralPubMedCrossRefGoogle Scholar
- Foxe, J. J., Molholm, S., Del Bene, V. A., Frey, H. P., Russo, N. N., Blanco, D., et al. (2013). Severe multisensory speech integration deficits in high-functioning school-aged children with autism spectrum disorder (ASD) and their resolution during early adolescence. Cerebral Cortex. doi: 10.1093/cercor/bht213.
- Lewkowicz, D. J. (2012). Development of multisensory temporal perception. In M. M. Murray & M. T. Wallace (Eds.), The neural bases of multisensory processes. Boca Raton, FL: CRC Press.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H, Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRefGoogle Scholar
- Ross, L. A., Molholm, S., Blanco, D., Gomez-Ramirez, M., Saint-Amour, D., & Foxe, J. J. (2011). The development of multisensory speech perception continues into the late childhood years. European Journal of Neuroscience, 33(12), 2329–2337. doi: 10.1111/j.1460-9568.2011.07685.x.PubMedCentralPubMedCrossRefGoogle Scholar
- Stevenson, R. A., Fister, J. K., Barnett, Z. P., Nidiffer, A. R., & Wallace, M. T. (2012a). Interactions between the spatial and temporal stimulus factors that influence multisensory integration in human performance. Experimental Brain Research. doi: 10.1007/s00221-012-3072-1.
- Stevenson, R. A., Magali, S., Susanne, F., Morgan, D. B., & Mark, T. W. (2014a). The impact of multisensory integration deficits on speech perception in children with autism spectrum disorders. Frontiers in Psychology, 5, 379.Google Scholar
- Stevenson, R. A., Siemann, J. K., Schneider, B. C., Eberly, H. E., Woynaroski, T. G., Camarata, S. M., et al. (2014b). Multisensory temporal integration in autism spectrum disorders. The Journal of Neuroscience, 34(3), 691–697. doi: 10.1523/jneurosci.3615-13.2014.PubMedCentralPubMedCrossRefGoogle Scholar
- Stevenson, R. A., Siemann, J. K., Woynaroski, T. G., Schneider, B. C., Eberly, H. E., Camarata, S. M., et al. (2014c). Brief report: Arrested development of audiovisual speech perception in autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(6), 1470–1477.Google Scholar
- Stevenson, R. A., Zemtsov, R. K., & Wallace, M. T. (2012b). Individual differences in the multisensory temporal binding window predict susceptibility to audiovisual illusions. Journal of Experimental Psychology: Human Perception and Performance. doi: 10.1037/a0027339.
- Taylor, N., Isaac, C., & Milne, E. (2010). A comparison of the development of audiovisual integration in children with autism spectrum disorders and typically developing children. Journal of Autism and Developmental Disorders, 40(11), 1403–1411. doi: 10.1007/s10803-010-1000-4.PubMedCrossRefGoogle Scholar
- von Helmholtz, H. (2005). Treatise on physiological optics (Vol. 3). Courier: Dover Publications.Google Scholar
- Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio: Harcourt Brace.Google Scholar
- Woynaroski, T. G., Kwakye, L. D., Foss-Feig, J. H., Stevenson, R. A., Stone, W. L., & Wallace, M. T. (2013). Multisensory speech perception in children with autism spectrum disorders. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-013-1836-5.