Journal of Autism and Developmental Disorders

, Volume 44, Issue 10, pp 2547–2557

Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study

  • Elina Jokiranta
  • Andre Sourander
  • Auli Suominen
  • Laura Timonen-Soivio
  • Alan S. Brown
  • Matti Sillanpää
Original Paper

Abstract

The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.

Keywords

Epilepsy Autism spectrum disorders Intellectual disability Gender Age at onset Population-based 

Abbreviations

ASD

Autism spectrum disorder

CPR

Finnish Central Population Register

FIPS-A

Finnish Prenatal Study of Autism and Autism Spectrum Disorders

FHDR

Finnish Hospital Discharge Register

FMBR

Finnish Medical Birth Register

ICD

International Classification of Diseases

ID

Intellectual disability

PDD-NOS

Pervasive developmental disorder—not otherwise specified

SE

Status epilepticus

THL

National Institute for Health and Welfare

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Elina Jokiranta
    • 1
    • 2
  • Andre Sourander
    • 1
    • 2
    • 3
  • Auli Suominen
    • 1
    • 2
  • Laura Timonen-Soivio
    • 1
    • 2
    • 4
  • Alan S. Brown
    • 3
    • 5
  • Matti Sillanpää
    • 6
    • 7
  1. 1.Department of Child PsychiatryUniversity of TurkuTurkuFinland
  2. 2.Turku University HospitalTurkuFinland
  3. 3.Department of Psychiatry, New York State Psychiatric InstituteColumbia University College of Physicians and SurgeonsNew YorkUSA
  4. 4.Department of Child NeurologyHelsinki University Central HospitalHelsinkiFinland
  5. 5.Department of Epidemiology, Mailman School of Public HealthColumbia UniversityNew YorkUSA
  6. 6.Department of Child NeurologyUniversity of TurkuTurkuFinland
  7. 7.Department of Public HealthUniversity of TurkuTurkuFinland

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