This study investigated time trends and associated factors of incidence rates of diagnosed autism spectrum disorders (ASD) across the lifespan from 1995 to 2010, using data from the Danish Psychiatric Central Research Registry. First time diagnosis of childhood autism, atypical autism, Asperger’s syndrome, or pervasive developmental disorder—unspecified (PDD-NOS) were identified, incidence rates were calculated, and data were fitted using non-linear least squares methods. A total of 14.997 patients were identified and incidence rates for ASD increased from 9.0 to 38.6 per 100,000 person years during the 16-year period. The increases were most pronounced in females, adolescents, adults, and patients with Asperger’s syndrome and PDD-NOS.
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Atladottir, H. O., Parner, E. T., Schendel, D., Dalsgaard, S., Thomsen, P. H., & Thorsen, P. (2007). Time trends in reported diagnoses of childhood neuropsychiatric disorders: A Danish cohort study. Archives of Pediatric and Adolescent Medicine, 161, 193–198.
Barbaresi, W. J., Colligan, R. C., Weaver, A. L., & Katusic, S. K. (2009). The incidence of clinically diagnosed versus research-identified autism in Olmsted County, Minnesota, 1976–1997: results from a retrospective, population-based study. Journal of Autism and Developmental Disorders, 39, 464–470.
Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2005). The incidence of autism in Olmsted County, Minnesota, 1976–1997: Results from a population-based study. Archives of Pediatric and Adolescent Medicine, 159, 37–44.
Burstyn, I., Sithole, F., & Zwaigenbaum, L. (2010). Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Diseases in Canada, 30, 125–134.
Chien, I. C., Lin, C. H., Chou, Y. J., & Chou, P. (2011). Prevalence and incidence of autism spectrum disorders among national health insurance enrollees in Taiwan from 1996 to 2005. Journal of Child Neurology, 26, 830–834.
Davidovitch, M., Hemo, B., Manning-Court, P., & Fombonne, E. (2013). Prevalence and incidence of autism spectrum disorder in an Israeli population. Journal of Autism and Developmental Disorders, 43, 785–793.
Davidovitch, M., Holtzman, G., & Tirosh, E. (2001). Autism in the Haifa area: An epidemiological perspective. The Israeal Medical Association Journal, 3, 188–189.
Elsabbagh, M., Divan, G., Koh, Y. J., Kim, Y. S., Kauchali, S., Marcin, C., et al. (2012). Global prevalence of autism and other pervasive developmental disorders. Autism Research, 5, 160–179.
Feng, L., Li, C., Chiu, H., Lee, T. S., Spencer, M. D., & Wong, J. C. (2013). Autism spectrum disorder in Chinese populations: A brief review. Asia-Pacific Psychiatry, 5, 54–60.
Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry, 66(Suppl 10), 3–8.
Fountain, C., King, M. D., & Bearman, P. S. (2011). Age of diagnosis for autism: individual and community factors across 10 birth cohorts. Journal of Epidemiology and Community Health, 65, 503–510.
Hertz-Picciotto, I., & Delwiche, L. (2009). The rise in autism and the role of age at diagnosis. Epidemiology, 20, 84–90.
Huerta, M., Bishop, S. L., Duncan, A., Hus, V., & Lord, C. (2012). Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders. American Journal of Psychiatry, 169, 1056–1064.
Keyes, K. M., Susser, E., Cheslack-Postava, K., Fountain, C., Liu, K., & Bearman, P. S. (2012). Cohort effects explain the increase in autism diagnosis among children born from 1992 to 2003 in California. International Journal of Epidemiology, 41, 495–503.
Kielinen, M., Linna, S. L., & Moilanen, I. (2000). Autism in Northern Finland. European Child and Adolescent Psychiatry, 9, 162–167.
Kirkovski, M., Enticott, P. G., Fitzgerald, P. B. (2013). A review of the role of female gender in autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(11), 2584–2603.
Kopp, S., Kelly, K. B., & Gillberg, C. (2010). Girls with social and/or attention deficits: a descriptive study of 100 clinic attenders. Journal of Attention Disorders, 14, 167–181.
Lauritsen, M. B., Jorgensen, M., Madsen, K. M., Lemcke, S., Toft, S., Grove, J., et al. (2010). Validity of childhood autism in the Danish Psychiatric Central Register: Findings from a cohort sample born 1990–1999. Journal of Autism and Developmental Disorders, 40, 139–148.
Lauritsen, M. B., Pedersen, C. B., & Mortensen, P. B. (2004). The incidence and prevalence of pervasive developmental disorders: A Danish population-based study. Psychological Medicine, 34, 1339–1346.
Liu, K. Y., King, M., & Bearman, P. S. (2010). Social influence and the autism epidemic. American Journal of Sociology, 115, 1387–1434.
Manning, S. E., Davin, C. A., Barfield, W. D., Kotelchuck, M., Clements, K., Diop, H., et al. (2011). Early diagnoses of autism spectrum disorders in Massachusetts birth cohorts, 2001–2005. Pediatrics, 127, 1043–1051.
Munk-Jorgensen, P., & Ostergaard, S. D. (2011). Register-based studies of mental disorders. Scandinavian Journal of Public Health, 39, 170–174.
Nassar, N., Dixon, G., Bourke, J., Bower, C., Glasson, E., de Klerk, N., et al. (2009). Autism spectrum disorders in young children: Effect of changes in diagnostic practices. International Journal of Epidemiology, 38, 1245–1254.
Parner, E. T., Schendel, D. E., & Thorsen, P. (2008). Autism prevalence trends over time in Denmark: Changes in prevalence and age at diagnosis. Archives of Pediatrics and Adolescent Medicine, 162, 1150–1156.
Powell, J. E., Edwards, A., Edwards, M., Pandit, B. S., Sungum-Paliwal, S. R., & Whitehouse, W. (2000). Changes in the incidence of childhood autism and other autistic spectrum disorders in preschool children from two areas of the West Midlands, UK. Developmental Medicine and Child Neurology, 42, 624–628.
Smeeth, L., Cook, C., Fombonne, P. E., Heavey, L., Rodrigues, L. C., Smith, P. G., et al. (2004). Rate of first recorded diagnosis of autism and other pervasive developmental disorders in United Kingdom general practice, 1988 to 2001. BMC Medicine, 2, 39.
STATA. (2012). STATA Data analysis and statistical software.
van der Ven, E., Termorshuizen, F., Laan, W., Breetvelt, E. J., van Os, J., & Selten, J. P. (2013). An incidence study of diagnosed autism-spectrum disorders among immigrants to the Netherlands. Acta Psychiatrica Scandinavica, 128, 54–60.
Van Meter, K. C., Christiansen, L. E., Delwiche, L. D., Azari, R., Carpenter, T. E., & Hertz-Picciotto, I. (2010). Geographic distribution of autism in California: A retrospective birth cohort analysis. Autism Research, 3, 19–29.
Wazana, A., Bresnahan, M., & Kline, J. (2007). The autism epidemic: Fact or artifact? Journal of the American Academy of Child and Adolescent Psychiatry, 46, 721–730.
Williams, K., Glasson, E. J., Wray, J., Tuck, M., Helmer, M., Bower, C. I., et al. (2005). Incidence of autism spectrum disorders in children in two Australian states. The Medical Journal of Australia, 182, 108–111.
Wong, V. C., & Hui, S. L. (2008). Epidemiological study of autism spectrum disorder in China. Journal of Child Neurology, 23, 67–72.
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Jensen, C.M., Steinhausen, H. & Lauritsen, M.B. Time Trends Over 16 Years in Incidence-Rates of Autism Spectrum Disorders Across the Lifespan Based on Nationwide Danish Register Data. J Autism Dev Disord 44, 1808–1818 (2014). https://doi.org/10.1007/s10803-014-2053-6