Attenuated Auditory Event-Related Potentials and Associations with Atypical Sensory Response Patterns in Children with Autism
- 1.3k Downloads
Neurobiological underpinnings of unusual sensory features in individuals with autism are unknown. Event-related potentials elicited by task-irrelevant sounds were used to elucidate neural correlates of auditory processing and associations with three common sensory response patterns (hyperresponsiveness; hyporesponsiveness; sensory seeking). Twenty-eight children with autism and 39 typically developing children (4–12 year-olds) completed an auditory oddball paradigm. Results revealed marginally attenuated P1 and N2 to standard tones and attenuated P3a to novel sounds in autism versus controls. Exploratory analyses suggested that within the autism group, attenuated N2 and P3a amplitudes were associated with greater sensory seeking behaviors for specific ranges of P1 responses. Findings suggest that attenuated early sensory as well as later attention-orienting neural responses to stimuli may underlie selective sensory features via complex mechanisms.
KeywordsAutism spectrum disorder Sensory processing Event-related potentials P1 N2 P3a
This research was supported in part by the Eunice Kennedy Shriver National Institute for Child Health and Human Development (R01-HD42168; T32-HD40127 to S. E. S.). We thank the families whose participation made this study possible and the staff who collected the data. We also acknowledge the Neurodevelopmental Disorders Research Center Autism Subject Registry at The University of North Carolina at Chapel Hill and the invaluable assistance of Don Trull in developing the EEG demonstration video (NICHD, P30HD03110).
- Aiken, L., & West, S. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage Publications.Google Scholar
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
- Baranek, G. T., David, F. J., Poe, M. D., Stone, W. L., & Watson, L. R. (2006). Sensory Experiences Questionnaire: Discriminating sensory features in young children with autism, developmental delays, and typical development. Journal of Child Psychology and Psychiatry, 47(6), 591–601.PubMedCrossRefGoogle Scholar
- Baranek, G. T., Watson, L. R., Boyd, B. A., Poe, M. D., David, F. J., & McGuire, L. (2013). Hyporesponsiveness to social and nonsocial sensory stimuli in children with autism, children with developmental delays, and typically developing children. Development and Psychopathology, 25, 307–320.PubMedCentralPubMedCrossRefGoogle Scholar
- Ceponiene, R., Lepistö, T., Shestakova, A., Vanhala, R., Alku, P., Näätänen, R., et al. (2003). Speech-sound-selective auditory impairment in children with autism: They can perceive but do not attend. Proceedings of the National Academy of Sciences of the United States of America, 100(9), 5567–5572.PubMedCentralPubMedCrossRefGoogle Scholar
- Cheour, M. (2007). Development of mismatch negativity (MMN) during infancy. In M. De Haan (Ed.), Infant EEG and event-related potentials (pp. 19–30). London: Psychology Press.Google Scholar
- Dunn, W. (1999). Sensory profile. San Antonio, TX: Psychological Corporation.Google Scholar
- Fox, J. (1991). Regression diagnostics. Newbury Park, CA: Sage Publications.Google Scholar
- Jansson-Verkasalo, E., Ruusuvirta, T., Huotilainen, M., Alku, P., Kushnerenko, E., Suominen, K., et al. (2010). Atypical perceptual narrowing in prematurely born infants is associated with compromised language acquisition at 2 years of age. BMC Neuroscience, 11, 88.PubMedCentralPubMedCrossRefGoogle Scholar
- Lincoln, A. J., Courchesne, E., Harms, L., & Allen, M. (1993). Contextual probability evaluation in autistic, receptive developmental language disorder, and control children: Event-related brain potential evidence. Journal of Autism and Developmental Disorders, 23(1), 37–58.PubMedCrossRefGoogle Scholar
- Lincoln, A. J., Courchesne, E., Harms, L., & Allen, M. (1995). Sensory modulation of auditory stimuli in children with autism and receptive developmental language disorder: Event-related brain potential evidence. Journal of Autism and Developmental Disorders, 25, 521–529.PubMedCrossRefGoogle Scholar
- Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2012). Autism diagnostic observation schedule (ADOS-2) (2nd ed.). Torrence, CA: Western Psychological Services.Google Scholar
- Mullen, E. M. (1995). Mullen scales of early learning (AGS edition). Los Angeles, CA: Western Psychological.Google Scholar
- Oostenveld, R., Fries, P., Maris, E., & Schoffelen, J.-M. (2011). FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Computational Intelligence and Neuroscience, 2011, Art. ID 156869. doi: 10.1155/2011/156869.
- Orekhova, E. V., Tsetlin, M. M., Butorina, A. V., Novikova, S. I., Gratchev, V. V., Sokolov, P. A, et al. (2012). Auditory cortex responses to clicks and sensory modulation difficulties in children with autism spectrum disorders (ASD). PLoS One, 7(6), e39906. doi: 10.1371/journal.pone.0039906.
- Roid, G. H. (2003). Stanford-Binet Intelligence Scales (SB5). Riverside, IL: Rolling Meadows.Google Scholar
- Roid, G. H., & Miller, L. J. (1997). Leiter International Performance Scale–Revised. Wood Dale, IL: Stoelting Co.Google Scholar
- Schopler, E., Reichler, R. J., & Renner, B. R. (1986). The Childhood Autism Rating Scale (CARS): For diagnostic screening and classification of autism. New York, NY: Irvington.Google Scholar
- Sparrow, S. S., Balla, D. A., & Cichetti, D. V. (1984). Vineland Adaptive Behavior Scales: Interview edition, expanded form manual. Circle Pines, MN: American Guidance Service.Google Scholar
- Tonnquist-Uhlen, I. (1996). Topography of auditory evoked cortical potentials in children with severe language impairment. Scandinavian Audiology Supplement, 25(44), 1–40.Google Scholar
- Watson, L. R., Patten, E., Baranek, G. T., Poe, M., Boyd, B. A., Freuler, A., et al. (2011). Differential associations between sensory response patterns and language, social, and communication measures in children with autism or other developmental disabilities. Journal of Speech, Language, and Hearing Research, 54(6), 1562–1576.PubMedCentralPubMedCrossRefGoogle Scholar