Maternal Diabetes and the Risk of Autism Spectrum Disorders in the Offspring: A Systematic Review and Meta-Analysis
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We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case–control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case–control studies showed significant associations. The pooled relative risk and 95 % confidence interval (CI) among cohort studies was 1.48 (1.25–1.75, p < 0.001). For case–control studies, the pooled odds ratio and 95 % CI was 1.72 (1.24–2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring.
KeywordsAutism spectrum disorders Diabetes Pregnancy
Autism diagnostic interview-revised
The autism diagnostic observation schedule
Autism spectrum disorders
The childhood autism rating scale
The diagnostic and statistical manual of mental disorders, fourth edition
International classification of diseases
This study was funded by the National Natural Science Foundation of China (No. 81172687) and the Doctoral Fund of Ministry of Education of China (No. 20110171110053). Dr. Wei Bao was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, USA.
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