Journal of Autism and Developmental Disorders

, Volume 44, Issue 3, pp 609–614 | Cite as

The Autism Mental Status Exam: Sensitivity and Specificity Using DSM-5 Criteria for Autism Spectrum Disorder in Verbally Fluent Adults

  • David Grodberg
  • Paige M. Weinger
  • Danielle Halpern
  • Michael Parides
  • Alexander Kolevzon
  • Joseph D. Buxbaum
Original Paper

Abstract

The phenotypic heterogeneity of adults suspected of autism spectrum disorder (ASD) requires a standardized diagnostic approach that is feasible in all clinical settings. The autism mental status exam (AMSE) is an eight-item observational assessment that structures the observation and documentation of social, communicative and behavioral signs and symptoms of ASD. Previous findings indicate high classification accuracy when compared to the autism diagnostic observation schedule in a non-stratified population of high-risk patients suspected of having ASD. This protocol investigates the sensitivity and specificity of AMSE scores using DSM-5 criteria for ASD in a sample of high-risk verbally fluent adults. Findings indicate an optimized sensitivity of 0.91 and a specificity of 0.93 for this group. Because of its high clinical utility, the AMSE holds promise as a diagnostic assessment tool that can support one’s clinical diagnosis of ASD in high-risk adults.

Keywords

Autism mental status exam Mental status exam Autism spectrum disorder DSM-5 ADOS Autism diagnostic assessment 

Notes

Acknowledgments

We would like to thank all of our participants and their families. We would also like to acknowledge the psychologists and research coordinators who assisted with data collection. This study was supported by the Beatrice and Samuel A. Seaver Foundation and by grant KL2 TR000069.

References

  1. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: American Psychiatric Association.Google Scholar
  2. Bastiaansen, J. A., Meffert, H., Hein, S., Huizinga, P., Ketelaars, C., Pijnenborg, M., et al. (2011). Diagnosing autism spectrum disorders in adults: the use of autism diagnostic observation schedule (ADOS) module 4. Journal of Autism and Developmental Disorders, 41(9), 1256–1266.CrossRefPubMedCentralPubMedGoogle Scholar
  3. Brugha, T. S., McManus, S., Bankart, J., Scott, F., Purdon, S., Smith, J., et al. (2011). Epidemiology of autism spectrum disorders in adults in the community in England. Archives of General Psychiatry, 68(5), 459–465.CrossRefPubMedGoogle Scholar
  4. Constantino, J. N., & Gruber, C. P. (2005). Social responsiveness scale (SRS). Los Angeles: Western Psychological Services.Google Scholar
  5. Grodberg, D., Weinger, P. M., Kolevzon, A., Soorya, L., & Buxbaum, J. D. (2012). Brief report: the autism mental status examination: development of a brief autism-focused exam. Journal of Autism and Developmental Disorders, 42(3), 455–459.CrossRefPubMedGoogle Scholar
  6. Johnson, S. A., Filliter, J. H., & Murphy, R. R. (2009). Discrepancies between self- and parent-perceptions of autistic traits and empathy in high functioning children and adolescents on the autism spectrum. Journal of Autism and Developmental Disorders, 39(12), 1706–1714.CrossRefPubMedGoogle Scholar
  7. Lord, C., Rutter, M., DiLavore, P., & Risi, S. (1999). Autism diagnostic observation schedule manual. Los Angeles: Western Psychological Services.Google Scholar
  8. Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., et al. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45(9), 1094–1103.CrossRefPubMedGoogle Scholar
  9. Ritvo, R. A., Ritvo, E. R., Guthrie, D., Ritvo, M. J., Hufnagel, D. H., McMahon, W., et al. (2011). The Ritvo Autism asperger diagnostic scale-revised (RAADS-R): a scale to assist the diagnosis of autism spectrum disorder in adults: an international validation study. Journal of Autism and Developmental Disorders, 41(8), 1076–1089.CrossRefPubMedCentralPubMedGoogle Scholar
  10. Rutter, M., Bailey, A., & Lord, C. (2003a). Social communication questionnaire. Los Angeles: Western Psychological Services.Google Scholar
  11. Rutter, M., LeCouteur, A., & Lord, C. (2003b). Autism diagnostic interview-revised. Western Psychological Services: Los Angeles.Google Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • David Grodberg
    • 1
  • Paige M. Weinger
    • 2
  • Danielle Halpern
    • 1
  • Michael Parides
    • 3
  • Alexander Kolevzon
    • 1
  • Joseph D. Buxbaum
    • 4
  1. 1.Department of Psychiatry, Seaver Autism Center for Research and TreatmentIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Pediatrics Department, Mailman Center for Child DevelopmentUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of Health Evidence and Policy, Mount Sinai Center for BiostatisticsIcahn School of Medicine at Mount SinaiNew YorkUSA
  4. 4.Departments of Psychiatry, Genetics and Genomic Sciences, and Neuroscience, Seaver Autism Center for Research and TreatmentIcahn School of Medicine at Mount SinaiNew YorkUSA

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