Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial
The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day ‘live-in’ intervention using a double-blind randomized control trial. 38 male youths (7–16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent–child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective.
KeywordsAutism Oxytocin Children Randomized controlled trial
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text revision): DSM-IV-TR. Washington, DC: American Psychiatric Association.Google Scholar
- Baron-Cohen, S. (2007). Mind reading the interactive guide to emotions. London: Jessica Kingsley Publishers.Google Scholar
- Bellini, S., & Akullian, J. (2007). A meta-analysis of video modelling and video self-modeling interventions for children and adolescents with autism spectrum disorders. Council for Exceptional Children, 73, 264–287.Google Scholar
- Campbell, D. B., Datta, D., Jones, S. T., Lee, E. B., Sutcliffe, J. S., Hammock, E. A. D., et al. (2011). Association of oxytocin receptor (OXTR) gene variants with multiply phenotype domains of autism spectrum disorder. Journal of Neurodevelopmental Disorders, 3, 101–112.CrossRefPubMedCentralPubMedGoogle Scholar
- Constantino, J. N., & Gruber, C. P. (2005). Social Responsiveness Scale (SRS) manual. Los Angeles, CA: Western Psychological Services.Google Scholar
- Dadds, M. R., Hawes, D., & Merz, S. (2004). The UNSW facial emotion task. Sydney: Department of Psychology, University of New South Wales.Google Scholar
- Dawson, G., Berniers, R., & Ring, R. H. (2012). Social attention: a possible early indicator of efficacy in autism clinical trials. Journal of Neurological Disorders, 4(11), 1–12.Google Scholar
- Gresham, F. M., & Elliot, S. N. (1990). Social skills rating scale. Circle Pines, MN: American Guidance Service.Google Scholar
- Kennedy, H. (2011). What is video interaction guidance (VIG)? In H. Kennedy, M. Lawlor, & L. Todd (Eds.), Video interaction guidance: A relationship-based intervention to promote attunement, empathy and wellbeing. London: Jessica Kingsley Publishers.Google Scholar
- MacDonald, E., & Dadds, M. R. (2010). Family observation schedule—Autism spectrum disorders. Unpublished manuscript, University of New South Wales. Available from authors.Google Scholar
- Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., et al. (2013). Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms. Autism Research. February 14. doi:10.1002/aur.1270.
- Novartis Pharmaceuticals. (2009). Novartis Australia health care professionals. Available at http://www.novartis.com.au/products_healthcare.html.
- Pasalich, D., & Dadds, M. R. (2009). Family observation schedule VI. Unpublished manuscript, University of New South Wales. Available from authors.Google Scholar
- Patterson, G. R. (1982). A social learning approach (vol 3): Coercive family process. Eugene, OR: Castalia Publishing Company.Google Scholar
- Schopler, E. C., Reichler, R. J., & Renner, B. R. (1988). The Childhood Autism Rating Scale (CARS). Los Angeles, CA: Western Psychological Services.Google Scholar
- Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum: Prevalence, comorbidity and associated factors in a population-derived sample. Journal of the American Academy of Child & Adolescent Psychiatry, 47, 921–929.CrossRefGoogle Scholar
- Tachibana, M., Kagitani-Shimono, K., Mohri, I., Yamamoto, T., Sanefuji, W., Nakamura, A., et al. (2013). Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 23(2), 123–127. doi:10.1089/cap.2012.0048.CrossRefPubMedGoogle Scholar
- The OSU Research Unit on Paediatric Psychopharmacology. (2005a). OSU Autism Rating Scale-DSM-IV (OARS-4). Columbus, OH: The OSU Research Unit on Paediatric Psychopharmacology.Google Scholar
- The OSU Research Unit on Paediatric Psychopharmacology. (2005b). OSU autism CGI. Columbus, OH: The OSU Research Unit on Paediatric Psychopharmacology.Google Scholar
- Wechsler, D. (2005). Wechsler Intelligence Scale for children (WISC-IV) (4th ed.). Sydney, Australia: Harcourt Assessment.Google Scholar