Use of Dysmorphology for Subgroup Classification on Autism Spectrum Disorder in Chinese Children

  • Virginia C. N. Wong
  • Cecilia K. Y. Fung
  • Polly T. Y. Wong
Original Paper


Data from 1,261 Chinese Autistic Spectrum Disorder (ASD) patients were evaluated and categorized into dysmorphic (10.79 %) and non-dysmorphic groups (89.21 %) upon physical examination by the presence of dysmorphic features. Abnormal MRI/CT result, IQ scores and epilepsy were significantly associated with the dysmorphic group of ASD children. However, gender, EEG abnormality and family history and recurrence of ASD were not found to be significantly different between group statuses. It is suggested that results collected from the Chinese population generally resembles that found in the Caucasians with ethnical differences still present. Current study supports the result shown in Miles’ study (Miles et al. in Am J Med Genet 135A:171–180, 2005), in which heterogeneity subtypes of autism of different genetic origins which could be distinguished by presence of dysmorphic features on the patients.


Autism Spectrum Disorder Dysmorphology Subgroup classification 



The authors would like to acknowledge Ms. Ann Wong for her kind assistance in statistical analysis.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Virginia C. N. Wong
    • 1
    • 2
  • Cecilia K. Y. Fung
    • 1
    • 2
  • Polly T. Y. Wong
    • 1
    • 2
  1. 1.Division of Child Neurology/Developmental Paediatrics/Neurohabilitation, Department of Pediatrics and Adolescent MedicineThe University of Hong KongHong KongChina
  2. 2.Division of Neurodevelopmental Paediatrics, Department of Pediatrics and Adolescent MedicineThe University of Hong KongHong KongChina

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