Functional Neuroimaging of Social and Nonsocial Cognitive Control in Autism
This study investigated cognitive control of social and nonsocial information in autism using functional magnetic resonance imaging. Individuals with autism spectrum disorders (ASDs) and a neurotypical control group completed an oddball target detection task where target stimuli were either faces or nonsocial objects previously shown to be related to circumscribed interests in autism. The ASD group demonstrated relatively increased activation to social targets in right insular cortex and in left superior frontal gyrus and relatively decreased activation to nonsocial targets related to circumscribed interests in multiple frontostriatal brain regions. Findings suggest that frontostriatal recruitment during cognitive control in ASD is contingent on stimulus type, with increased activation for social stimuli and decreased activation for nonsocial stimuli related to circumscribed interests.
KeywordsAutism Functional magnetic resonance imaging; cognitive control Repetitive behaviors Frontostriatal
This research was supported by R01 MH073402 (JWB and GSD), K23 MH081285 (GSD), and H325D070011 (AS). Assistance for this study was provided by the Participant Registry Core of the Carolina Institute for Developmental Disabilities (P30 HD03110). The authors thank Josh Bizzell, Chris Petty, Zoe Englander, and Todd Harshbarger for assistance with image analysis, MRI technologists Susan Music, Natalie Goutkin, and Luke Poole for assistance with data acquisition, and BIAC Director Dr. Allen Song for assistance with various aspects of this project. Finally, we gratefully acknowledge the participation of individuals with autism in this research.
- Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17.PubMedCrossRefGoogle Scholar
- Bodfish, J. W., Symons, F. W., & Lewis, M. H. (1999). The Repetitive Behavior Scale-Revised, Western Carolina Center Research Reports.Google Scholar
- Dichter, G. S. (2012). Functional magnetic resonance imaging of autism spectrum disorders. Dialogues Clinical Neuroscience, 14(3), 319–351.Google Scholar
- Honey, E., McConachie, H., Randle, V., Shearer, H., & Couteur, A. S. (2006). One-year change in repetitive behaviours in young children with communication disorders including autism. Journal of Autism and Developmental Disorders, 38(8), 1439–1450.Google Scholar
- Huettel, S. A. (2004). Non-linearities in the blood-oxygenation-level dependent (BOLD) response measured by functional magnetic resonance imaging (fMRI). In Conf Proc IEEE Eng Med Biol Soc, 6, 4413–4416.Google Scholar
- Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child, 2, 217–250.Google Scholar
- Lezak, M. D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRefGoogle Scholar
- Mazziotta, J., Toga, A., Evans, A., Fox, P., Lancaster, J., Zilles, K., et al. (2001). A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philosophical Transactions of the Royal Society of London, 356(1412), 1293–1322.PubMedCrossRefGoogle Scholar
- Richey, J. A., Rittenberg, A., Hughes, L., Damiano, C. R., Sabatino, A., Miller, S., et al. (2013). Common and distinct neural features of social and non-social reward processing in autism and social anxiety disorder. Social Cognitive and Affective Neuroscience. doi: 10.1093/scan/nss146.
- Scahill, L., McDougle, C. J., Williams, S. K., Dimitropoulos, A., Aman, M. G., McCracken, J. T., et al. (2006). Children's yale-brown obsessive compulsive scale modified for pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45(9), 1114–1123.PubMedCrossRefGoogle Scholar
- Solomon, M., Ozonoff, S., Ursu, S., Ravizza, S., Cummings, N., Ly, S., et al. (2009). The neural substrates of cognitive control deficits in autism spectrum disorders. Neuropsychologia, 47(12), 2515–2526.Google Scholar
- Ward, B. D. (2000). Simultaneous inference for fMRI data. Medical College of Wisconsin, Milwaukee: Biophysics Research Institute.Google Scholar
- Weschler, D. (1999). Weschler Abbreviated Scale of Intelligence (WASI). San Antonio, TX: Harcourt Assessment.Google Scholar