Journal of Autism and Developmental Disorders

, Volume 43, Issue 12, pp 2903–2913 | Cite as

Functional Neuroimaging of Social and Nonsocial Cognitive Control in Autism

  • Antoinette Sabatino
  • Alison Rittenberg
  • Noah J. Sasson
  • Lauren Turner-Brown
  • James W. Bodfish
  • Gabriel S. Dichter
Original Paper

Abstract

This study investigated cognitive control of social and nonsocial information in autism using functional magnetic resonance imaging. Individuals with autism spectrum disorders (ASDs) and a neurotypical control group completed an oddball target detection task where target stimuli were either faces or nonsocial objects previously shown to be related to circumscribed interests in autism. The ASD group demonstrated relatively increased activation to social targets in right insular cortex and in left superior frontal gyrus and relatively decreased activation to nonsocial targets related to circumscribed interests in multiple frontostriatal brain regions. Findings suggest that frontostriatal recruitment during cognitive control in ASD is contingent on stimulus type, with increased activation for social stimuli and decreased activation for nonsocial stimuli related to circumscribed interests.

Keywords

Autism Functional magnetic resonance imaging; cognitive control Repetitive behaviors Frontostriatal 

Notes

Acknowledgments

This research was supported by R01 MH073402 (JWB and GSD), K23 MH081285 (GSD), and H325D070011 (AS). Assistance for this study was provided by the Participant Registry Core of the Carolina Institute for Developmental Disabilities (P30 HD03110). The authors thank Josh Bizzell, Chris Petty, Zoe Englander, and Todd Harshbarger for assistance with image analysis, MRI technologists Susan Music, Natalie Goutkin, and Luke Poole for assistance with data acquisition, and BIAC Director Dr. Allen Song for assistance with various aspects of this project. Finally, we gratefully acknowledge the participation of individuals with autism in this research.

Supplementary material

10803_2013_1837_MOESM1_ESM.pdf (51 kb)
Supplementary material 1 (PDF 51 kb)

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Antoinette Sabatino
    • 1
    • 2
  • Alison Rittenberg
    • 2
  • Noah J. Sasson
    • 3
  • Lauren Turner-Brown
    • 2
    • 5
  • James W. Bodfish
    • 4
  • Gabriel S. Dichter
    • 1
    • 2
    • 5
    • 6
  1. 1.Department of PsychologyUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Carolina Institute for Developmental DisabilitiesUniversity of North Carolina at Chapel HillChapel HillUSA
  3. 3.School of Behavioral and Brain SciencesThe University of Texas at DallasRichardsonUSA
  4. 4.Departments of Hearing and Speech Sciences and PsychiatryVanderbilt UniversityNashvilleUSA
  5. 5.Department of PsychiatryUniversity of North Carolina at Chapel HillChapel HillUSA
  6. 6.Duke-UNC Brain Imaging and Analysis CenterDurhamUSA

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