Journal of Autism and Developmental Disorders

, Volume 43, Issue 11, pp 2502–2514 | Cite as

Intervention for Infants at Risk of Developing Autism: A Case Series

  • Jonathan GreenEmail author
  • Ming Wai Wan
  • Jeanne Guiraud
  • Samina Holsgrove
  • Janet McNally
  • Vicky Slonims
  • Mayada Elsabbagh
  • Tony Charman
  • Andrew Pickles
  • Mark Johnson
  • The BASIS Team
Original Paper


Theory and evidence suggest the potential value of prodromal intervention for infants at risk of developing autism. We report an initial case series (n = 8) of a parent-mediated, video-aided and interaction-focused intervention with infant siblings of autistic probands, beginning at 8–10 months of age. We outline the theory and evidence base behind this model and present data on feasibility, acceptability and measures ranging from parent-infant social interaction, to infant atypical behaviors, attention and cognition. The intervention proves to be both feasible and acceptable to families. Measurement across domains was successful and on larger samples promise to be an effective test of whether such an intervention in infancy will modify emergent atypical developmental trajectories in infants at risk for autism.


Autism Intervention Prodromal Infancy Parent–child interaction 



We acknowledge with thanks the generous collaboration from the originators of the original VIPP intervention (Femmie Juffer, Marian Bakermans Kranenberg, Marinus van IJzendoorn) that forms the basis of our intervention model. We are grateful for the enormous contributions BASIS families have made towards this study. The research was supported by awards from Autistica, Waterloo Foundation and Central Manchester Foundation NHS Trust to Jonathan Green; from the UK Economic and Social Research Council to Ming Wai Wan and Jonathan Green; Walport Academic Clinical Fellowship to Samina Holsgrove; and from the UK Medical Research Council (G0701484) and the BASIS funding consortium led by Autistica ( to M.H. Johnson.

Supplementary material

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Supplementary material 1 (DOC 73 kb)
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Supplementary material 2 (DOC 34 kb)
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Supplementary material 3 (DOC 40 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Jonathan Green
    • 1
    Email author
  • Ming Wai Wan
    • 2
  • Jeanne Guiraud
    • 3
  • Samina Holsgrove
    • 2
  • Janet McNally
    • 2
  • Vicky Slonims
    • 5
  • Mayada Elsabbagh
    • 3
  • Tony Charman
    • 4
  • Andrew Pickles
    • 6
  • Mark Johnson
    • 3
  • The BASIS Team
  1. 1.Institute of Brain, Behaviour and Mental HealthUniversity of ManchesterManchesterUK
  2. 2.Institute of Brain, Behaviour and Mental HealthUniversity of ManchesterManchesterUK
  3. 3.Centre for Brain and Cognitive Development, Department of Psychological Science, BirkbeckUniversity of LondonLondonUK
  4. 4.Department of Psychology, Institute of PsychiatryKing’s College LondonLondonUK
  5. 5.Guy’s and St Thomas’ NHS Foundation Trust/King’s College London, Great Maze PondLondonUK
  6. 6.Department of Biostatistics, Institute of PsychiatryKing’s College LondonLondonUK

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