Journal of Autism and Developmental Disorders

, Volume 43, Issue 8, pp 1784–1797

Empirically Based Phenotypic Profiles of Children with Pervasive Developmental Disorders: Interpretation in the Light of the DSM-5

  • Kirstin Greaves-Lord
  • Mart L. J. M. Eussen
  • Frank C. Verhulst
  • Ruud B. Minderaa
  • William Mandy
  • James J. Hudziak
  • Mark Peter Steenhuis
  • Pieter F. de Nijs
  • Catharina A. Hartman
Original Paper

DOI: 10.1007/s10803-012-1724-4

Cite this article as:
Greaves-Lord, K., Eussen, M.L.J.M., Verhulst, F.C. et al. J Autism Dev Disord (2013) 43: 1784. doi:10.1007/s10803-012-1724-4

Abstract

This study aimed to contribute to the Diagnostic and Statistical Manual (DSM) debates on the conceptualization of autism by investigating (1) whether empirically based distinct phenotypic profiles could be distinguished within a sample of mainly cognitively able children with pervasive developmental disorder (PDD), and (2) how profiles related to diagnoses and co-occurring behavioral and emotional problems. Six classes with distinct profiles were discerned. Three classes showed profiles not completely in line with the proposed DSM-5 conceptualization of autism. These classes included relatively many cognitively able individuals with PDD-not otherwise specified. However, profiles seemed to suit other diagnostic categories, such as social communication disorder. These alternative diagnoses could retain eligibility for services, and might adequately fit more specifically targeted interventions.

Keywords

Autism spectrum disorders DSM-5 Phenotypic profiles Comorbidity 

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Kirstin Greaves-Lord
    • 1
    • 2
  • Mart L. J. M. Eussen
    • 2
    • 1
  • Frank C. Verhulst
    • 1
  • Ruud B. Minderaa
    • 3
  • William Mandy
    • 4
  • James J. Hudziak
    • 5
  • Mark Peter Steenhuis
    • 3
  • Pieter F. de Nijs
    • 1
  • Catharina A. Hartman
    • 3
  1. 1.Department of Child and Adolescent Psychiatry/PsychologyErasmus Medical Center Rotterdam/Sophia Children’s HospitalRotterdamThe Netherlands
  2. 2.Yulius AcademyYulius Mental HealthDordrechtThe Netherlands
  3. 3.Department of PsychiatryUniversity Medical Center GroningenGroningenThe Netherlands
  4. 4.Division of Psychology & Language Sciences, Faculty of Brain SciencesUniversity College LondonLondonUK
  5. 5.Department of Psychiatry, Divisions of Child Psychiatry and Behavioral GeneticsUniversity of VermontBurlingtonUSA

Personalised recommendations