Standardizing ADOS Domain Scores: Separating Severity of Social Affect and Restricted and Repetitive Behaviors
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Standardized Autism Diagnostic Observation Schedule (ADOS) scores provide a measure of autism severity that is less influenced by child characteristics than raw totals (Gotham et al. in Journal of Autism and Developmental Disorders, 39(5), 693–705 2009). However, these scores combine symptoms from the Social Affect (SA) and Restricted and Repetitive Behaviors (RRB) domains. Separate calibrations of each domain would provide a clearer picture of ASD dimensions. The current study separately calibrated raw totals from the ADOS SA and RRB domains. Standardized domain scores were less influenced by child characteristics than raw domain totals, thereby increasing their utility as indicators of Social-Communication and Repetitive Behavior severity. Calibrated domain scores should facilitate efforts to examine trajectories of ASD symptoms and links between neurobiological and behavioral dimensions.
KeywordsAutism spectrum disorders Autism Diagnostic Observation Schedule Severity Social Affect Restricted and Repetitive Behaviors
This research was supported by a Dennis Weatherstone Predoctoral Fellowship to VH and National Institute of Mental Health grants T32-MH18921 to KG and R01MH081873 and RC1MH089721 to CL. We gratefully acknowledge Drs. Andrew Pickles, Christopher Gruber and Sheri Stegall for their consultation in preparation of this manuscript, as well as all of the families who participated in this research.
Conflict of interest
C. Lord receives royalties for the ADOS; profits from this study were donated to charity.
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders. Fourth Edition, Text Revision: DSM-IV-TR. Washington, DC: American Psychiatric Association.Google Scholar
- American Psychiatric Association. (2011). DSM-5 Development: A 09 Autism Spectrum Disorder. http://www.dsm5.org/ProposedRevisions/Pages/proposedrevision.aspx?rid=94. Accessed 04 March 2012.
- Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Psychology Press.Google Scholar
- Constantino, J. N., & Gruber, C. (2005). The Social Responsiveness Scale. Los Angeles: Western Psychological Services.Google Scholar
- Constantino, J. N., Hudziak, J. J., & Todd, R. D. (2003). Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 42(4), 458–467. doi: 10.1097/01.CHI.0000046811.95464.21.PubMedCrossRefGoogle Scholar
- Elliott, C. D. (1990). Differential Ability Scales. San Antonio: Psychological Corporation.Google Scholar
- Frazier, T. W., Youngstrom, E. A., Speer, L., Embacher, R., Law, P., Constantino, J., et al. (2012). Validation of proposed DSM-5 criteria for Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 51(1), 28–40. doi: 10.1016/j.jaac.2011.09.021.PubMedCrossRefPubMedCentralGoogle Scholar
- Huerta, M., Bishop, S. L., Duncan, A., Hus, V., & Lord, C. (in press). How many will we miss? Application of DSM 5 criteria to 3 samples of children with DSM-IV diagnoses of ASD. American Journal of Psychiatry.Google Scholar
- Hus, V., & Lord, C. (in press). Effects of child characteristics on the Autism Diagnostic Interview-Revised: Implications for use of scores as a measure of ASD severity. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-012-1576-y.
- Hus, V., Bishop, S., Gotham, K., Huerta, M., Pickles, A., & Lord, C. (in press). Factors influencing scores on the Social Responsiveness Scale. Journal of Child Psychology and Psychiatry. Google Scholar
- Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2). Torrance: Western Psychological Services.Google Scholar
- Luyster, R., Gotham, K., Guthrie, W., Coffing, M., Petrak, R., Pierce, K., et al. (2009). The autism diagnostic observation schedule—toddler module: a new module of a standardized diagnostic measure for autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(9), 1305–1320. doi: 10.1007/s10803-009-0746-z.PubMedCrossRefPubMedCentralGoogle Scholar
- Mattila, M.-L., Kielinen, M., Linna, S.-L., Jussila, K., Ebeling, H., Bloigu, R., Joseph, R. M., et al. (2011). Autism Spectrum Disorders according to “DSM-IV-TR” and comparison with “DSM-5” draft criteria: An epidemiological study. Journal of the American Academy of Child & Adolescent Psychiatry, 50(6), 583–592.e11.Google Scholar
- McPartland, J. C., Reichow, B., & Volkmar, F. R. (2012). Sensitivity and specificity of proposed DSM-5 diagnostic criteria for Autism Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 51(4), 368–383. doi: 10.1016/j.jaac.2012.01.007.PubMedCrossRefPubMedCentralGoogle Scholar
- Mullen, E. (1995). The Mullen Scales of Early Learning. Circle Pines: American Guidance Service, Inc.Google Scholar
- Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview-revised. Los Angeles: Western Psychological Services.Google Scholar
- World Health Organization. (1992). The ICD-10 classification of mental and behavioral disorder: Clinical descriptions and diagnostic guidelines. Geneva: World Health Organization.Google Scholar
- World Health Organization. (2012). International Classification of Diseases 11th Revision: Beta draft. http://apps.who.int/classifications/icd11/browse/f/en. Accessed 22 September 2012.