The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults
We tested whether in 85 healthy adults (18–29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities.
KeywordsADHD Autism ASD VBM Grey-matter sMRI
We thank Andries van der Leij and Romke Rouw for various fruitful discussions. We thank Sanne van den Bergh for assisting us with the manuscript preparation.
Conflict of interest
None of the authors, Hilde M. Geurts, K. Richard Ridderinkhof, and Steven H. Scholte, reported any biomedical financial interests of other potential conflicts of interest.
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