Journal of Autism and Developmental Disorders

, Volume 43, Issue 7, pp 1527–1538 | Cite as

Multisite Study of New Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers

  • So Hyun Kim
  • Audrey Thurm
  • Stacy Shumway
  • Catherine Lord
Original Paper


Using two independent datasets provided by National Institute of Health funded consortia, the Collaborative Programs for Excellence in Autism and Studies to Advance Autism Research and Treatment (n = 641) and the National Institute of Mental Health (n = 167), diagnostic validity and factor structure of the new Autism Diagnostic Interview (ADI-R) algorithms for toddlers and young preschoolers were examined as a replication of results with the 2011 Michigan sample (Kim and Lord in J Autism Dev Disord 42(1): 82-93, 2012). Sensitivities and specificities and a three-factor solution were replicated. Results suggest that the new ADI-R algorithms can be appropriately applied to existing research databases with children from 12 to 47 months and down to nonverbal mental ages of 10 months for diagnostic grouping.


Early diagnosis Autism spectrum disorders Autism diagnostic interview-revised 



We gratefully acknowledge the help of Kaite Gotham and Alice Kau as well as the families that participated in this research. This study was supported by National Institute of Mental Health (NIMH) R01MH066469, NIMH R25MH067723, National Institute of Health Intramural Research Program, NIMH, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, and Eunice Kennedy Shriver National Institute of Child Health and Human Development. One of the authors, Catherine Lord, receives royalties for the ADI-R and ADOS; profits related to this study were donated to charity.


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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • So Hyun Kim
    • 1
  • Audrey Thurm
    • 2
  • Stacy Shumway
    • 2
  • Catherine Lord
    • 3
  1. 1.Yale Child Study CenterYale University School of MedicineNew HavenUSA
  2. 2.Pediatrics and Developmental Neuroscience BranchNational Institute of Mental HealthBethesdaUSA
  3. 3.Center for Autism and the Developing BrainWeill Cornell Medical CollegeWhite PlainsUSA

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