Journal of Autism and Developmental Disorders

, Volume 43, Issue 4, pp 817–828 | Cite as

Prevalence and Onset of Regression within Autism Spectrum Disorders: A Meta-analytic Review

  • Brian D. Barger
  • Jonathan M. CampbellEmail author
  • Jaimi D. McDonough
Original Paper


Rates and onset of regression were meta-analyzed from 85 articles representing 29,035 participants with autism spectrum disorders (ASD). Overall prevalence rate for regression was 32.1, 95 % CI [29.5, 34.8] occurring at mean of 1.78 years, 95 % CI [1.67, 1.89]. Regression prevalence rates differed according to four types of regression: language regression, 24.9 %; language/social regression, 38.1 %; mixed regression, 32.5 %; and unspecified regression, 39.1 %. Regression prevalence also differed according to sampling method: population-based prevalence was 21.8 %, clinic-based prevalence was 33.6 %, and parent survey-based prevalence was 40.8 %. Risk of regression was equal for males and females, but higher for individuals diagnosed with autism versus another ASD. Later age of regression onset was predicted by older age of child.


Autism spectrum disorders Regression Meta-analysis 

Supplementary material

10803_2012_1621_MOESM1_ESM.doc (52 kb)
Supplementary material 1 (DOC 52 kb)


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Brian D. Barger
    • 1
  • Jonathan M. Campbell
    • 1
    • 2
    Email author
  • Jaimi D. McDonough
    • 1
  1. 1.Department of Educational Psychology and Instructional TechnologyUniversity of GeorgiaAthensUSA
  2. 2.Department of Educational, School, and Counseling PsychologyUniversity of KentuckyLexingtonUSA

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