Journal of Autism and Developmental Disorders

, Volume 44, Issue 10, pp 2392–2399 | Cite as

Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection

  • Julie Davidson
  • Robin P. Goin-Kochel
  • Lee Anne Green-Snyder
  • Rachel J. Hundley
  • Zachary Warren
  • Sarika U. PetersEmail author
Original Paper


The broad autism phenotype (BAP) refers to the phenotypic expression of an underlying genetic liability to autism, manifest in non-autistic relatives. This study examined the relationship among the Broad Autism Phenotype Questionnaire (BAPQ), Social Responsiveness Scale: Adult Research Version (SRS:ARV), and Family History Interview (FHI) in a large, multi-site study of 1,650 simplex families (Simons Simplex Collection). Correlations between the BAPQ and SRS:ARV Total scores were moderate, and correlations between FHI ratings and SRS:ARV and BAPQ were significant but weak. Overall, the results suggested that BAP traits occur at low rates in simplex families, and rates vary significantly depending upon the measure utilized. Implications include the need for multiple informants, and the assessment of distinct BAP traits in large-scale genetic studies of individuals with ASD.


Autism Broad autism phenotype 



This study was supported by the Simons Foundation. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, A. Klin, B. Peterson, C. Lord, C. Martin, C. Saulnier, C. Walsh, D. Geschwind, D. Grice, D. Ledbetter, D. Martin, E. Cook, E. Fombonne, E. Wijsman, J. Miles, J. Constantino, J. Piggot, J. Sutcliffe, M. State, O. Ousley, R. Bernier, R. Maxim, W. Stone). We appreciate obtaining access to phenotypic data on SFARI Base,*browse_collection/archive[sfari_collection_v6]/ui:view().


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Julie Davidson
    • 1
  • Robin P. Goin-Kochel
    • 2
  • Lee Anne Green-Snyder
    • 3
  • Rachel J. Hundley
    • 1
  • Zachary Warren
    • 1
  • Sarika U. Peters
    • 1
    Email author
  1. 1.Departments of Pediatrics and PsychiatryVanderbilt UniversityNashvilleUSA
  2. 2.Department of PediatricsBaylor College of MedicineHoustonUSA
  3. 3.Children’s Hospital of BostonBostonUSA

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