Journal of Autism and Developmental Disorders

, Volume 42, Issue 8, pp 1717–1728 | Cite as

Patterns of Contact with Hospital for Children with an Autism Spectrum Disorder: A Danish Register-Based Study

  • Hjördis Osk Atladóttir
  • Diana E. Schendel
  • Marlene B. Lauritsen
  • Tine Brink Henriksen
  • Erik T. Parner
Original paper

Abstract

The aim of this study was to study patterns of contact with hospital for children with autism spectrum disorder (ASD) using Danish population based register data. We included all children born in Denmark from 1994 through 2002. We found that children diagnosed with ASD had an increased rate of contact with hospital, almost regardless of the cause for the hospital contact. Given the overall association between hospital contact for various causes and ASD observed in these data, hospital data should be used cautiously in future studies searching for associations between a specific disease and ASD. If the increased rate of hospital contact overall for children with ASD is not considered, then misleading over interpretations might be made of observed associations between specific diseases and ASD.

Keywords

Autistic disorder Autism Hospitalization Admission Hospital contact Comorbidity 

Notes

Acknowledgments

Funding was provided by the Aarhus University Research Foundation, the Aase and Ejnar Danielsens Foundation, the Augustinus Foundation, and the Familien Hede Nielsens Foundation. The funding sources did not participate in any part of the performance of the study. The study was approved by the Danish Data Protection Agency and the Danish National Board of Health.

Conflict of interest

The authors have no conflict of interest with the results of this study.

References

  1. Andersen, T. F., Madsen, M., Jorgensen, J., Mellemkjoer, L., & Olsen, J. H. (1999). The Danish National Hospital Register. A valuable source of data for modern health sciences. Danish Medical Bulletin, 46, 263–268.PubMedGoogle Scholar
  2. Atladottir, H. O., Thorsen, P., Schendel, D. E., Ostergaard, L., Lemcke, S., & Parner, E. T. (2010). Association of hospitalization for infection in childhood with diagnosis of autism spectrum disorders: a Danish cohort study. Archives of Pediatrics and Adolescent Medicine, 164, 470–477.PubMedCrossRefGoogle Scholar
  3. Barcia, G., Posar, A., Santucci, M., & Parmeggiani, A. (2008). Autism and coeliac disease. Journal of Autism and Developmental Disorders, 38, 407–408.PubMedCrossRefGoogle Scholar
  4. Gardener, H., Spiegelman, D., & Buka, S. L. (2011). Perinatal and Neonatal Risk Factors for Autism: A Comprehensive Meta-Analysis. Pediatrics.Google Scholar
  5. Gillberg, C., & Coleman, M. (1996). Autism and medical disorders: a review of the literature. Developmental Medicine and Child Neurology, 38, 191–202.PubMedCrossRefGoogle Scholar
  6. Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Archives of Pediatrics and Adolescent Medicine, 160, 825–830.PubMedCrossRefGoogle Scholar
  7. Knudsen, L. B., & Olsen, J. (1998). The Danish Medical Birth Registry. Danish Medical Bulletin, 45, 320–323.PubMedGoogle Scholar
  8. Konstantareas, M. M., & Homatidis, S. (1987). Ear infections in autistic and normal children. Journal of Autism and Developmental Disorders, 17, 585–594.PubMedCrossRefGoogle Scholar
  9. Landa, R. J. (2008). Diagnosis of autism spectrum disorders in the first 3 years of life. Nature Clinical Practice. Neurology, 4, 138–147.PubMedCrossRefGoogle Scholar
  10. Lauritsen, M. B., Jorgensen, M., Madsen, K. M., Lemcke, S., Toft, S., Grove, J., et al. (2010). Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990–1999. Journal of Autism and Developmental Disorders, 40, 139–148.PubMedCrossRefGoogle Scholar
  11. Lauritsen, M. B., Mors, O., Mortensen, P. B., & Ewald, H. (2002). Medical disorders among inpatients with autism in Denmark according to ICD-8: a nationwide register-based study. Journal of Autism and Developmental Disorders, 32, 115–119.PubMedCrossRefGoogle Scholar
  12. Mason-Brothers, A., Ritvo, R. E., Freeman, S. J., & Jorde, B. L. (1993). The UCLA-University of Utah epidemiology survey of autism: Recurrent infections. European Child and Adolescent Psychiatry, 2, 79–90.CrossRefGoogle Scholar
  13. Milne, E., Griffiths, H., Buckley, D., & Scope, A. (2009). Vision in children and adolescents with autistic spectrum disorder: evidence for reduced convergence. Journal of Autism and Developmental Disorders, 39, 965–975.PubMedCrossRefGoogle Scholar
  14. MIng, X., Brimacombe, M., Chaaban, J., Zimmerman-Bier, B., & Wagner, G. C. (2008). Autism Spectrum Disorders: Concurrent Clinical Disorders. Journal of Child Neurology, 23, 6–13.CrossRefGoogle Scholar
  15. Munk-Jorgensen, P., & Mortensen, P. B. (1997). The Danish Psychiatric Central Register. Danish Medical Bulletin, 44, 82–84.PubMedGoogle Scholar
  16. Parner, E. T., Schendel, D. E., & Thorsen, P. (2008). Autism prevalence trends over time in Denmark: changes in prevalence and age at diagnosis. Archives of Pediatrics and Adolescent Medicine, 162, 1150–1156.PubMedCrossRefGoogle Scholar
  17. Pedersen, C. B., Gotzsche, H., Moller, J. O., & Mortensen, P. B. (2006). The Danish civil registration system. A cohort of eight million persons. Danish Medical Bulletin, 53, 441–449.PubMedGoogle Scholar
  18. Petersen, M. C., Kube, D. A., & Palmer, F. B. (2006). High Prevalence of Developmental Disabilities in Children Admitted to a General Pediatric Inpatient Unit. Journal of Developmental and Physical Disabilities, 18, 307–318.CrossRefGoogle Scholar
  19. Petersen, M. C., Kube, D. A., Whitaker, T. M., Graff, J. C., & Palmer, F. B. (2009). Prevalence of developmental and behavioral disorders in a pediatric hospital. Pediatrics, 123, e490–e495.PubMedCrossRefGoogle Scholar
  20. Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, U. S. 2. (2009). MMWR Surveill Summ., 58, 1–20.Google Scholar
  21. Ritvo, E. R., Mason-Brothers, A., Freeman, B. J., Pingree, C., Jenson, W. R., McMahon, W. M., et al. (1990). The UCLA-University of Utah epidemiologic survey of autism: the etiologic role of rare diseases. American Journal of Psychiatry, 147, 1614–1621.PubMedGoogle Scholar
  22. Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65, 599–606.PubMedCrossRefGoogle Scholar
  23. Stata Statistical Software. (2007). (Version Release 10.0) [Computer software]. College Station, TX: Stata Corporation.Google Scholar
  24. Tripp, G., Luk, S. L., Schaughency, E. A., & Singh, R. (1999). DSM-IV and ICD-10: a comparison of the correlates of ADHD and hyperkinetic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 156–164.PubMedCrossRefGoogle Scholar
  25. van den Heuvel, E., Starreveld, J. S., de Ru, M., Krauwer, V., & Versteegh, F. G. (2007). Somatic and psychiatric co-morbidity in children with attention deficit hyperactivity disorder. Acta Paediatrica, 96, 454–456.PubMedCrossRefGoogle Scholar
  26. Van Dyke, E. M. (2009). Autistic disorder: early interventions can improve outcomes. JAAPA, 22, 18–19.PubMedGoogle Scholar
  27. World Health Organization (1993). International classification of diseases, 10th revision.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Hjördis Osk Atladóttir
    • 1
  • Diana E. Schendel
    • 2
  • Marlene B. Lauritsen
    • 3
  • Tine Brink Henriksen
    • 4
  • Erik T. Parner
    • 5
  1. 1.Department of Public Health, Section of EpidemiologyUniversity of AarhusÅrhus C, AarhusDenmark
  2. 2.National Center on Birth Defects and Developmental DisabilitiesCenters for Disease Control and PreventionAtlantaUSA
  3. 3.Regional Centre for Child and Adolescent PsychiatryAarhus University HospitalRisskovDenmark
  4. 4.Perinatal Epidemiology Research Unit, Department of PediatricsAarhus University HospitalAarhusDenmark
  5. 5.Department of Public Health, Section of BiostatisticsUniversity of AarhusAarhusDenmark

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