Journal of Autism and Developmental Disorders

, Volume 42, Issue 8, pp 1630–1641

Exploring the Relationship Between Autism Spectrum Disorder and Epilepsy Using Latent Class Cluster Analysis

  • Michael L. Cuccaro
  • Roberto F. Tuchman
  • Kara L. Hamilton
  • Harry H. Wright
  • Ruth K. Abramson
  • Jonathan L. Haines
  • John R. Gilbert
  • Margaret Pericak-Vance
Original Paper


Epilepsy co-occurs frequently in autism spectrum disorders (ASD). Understanding this co-occurrence requires a better understanding of the ASD-epilepsy phenotype (or phenotypes). To address this, we conducted latent class cluster analysis (LCCA) on an ASD dataset (N = 577) which included 64 individuals with epilepsy. We identified a 5-cluster solution with one cluster showing a high rate of epilepsy (29%), earlier age at first recognition, and high rates of repetitive object use and unusual sensory interests. We also conducted LCCA on an ASD-epilepsy subset from the overall dataset (N = 64) which yielded three clusters, the largest of which had impairments in language and motor development; the remaining clusters, while not as developmentally impaired were characterized by different levels of repetitive and sensory behaviors.


Autism spectrum disorders Epilepsy Latent class cluster analysis Phenotype 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Michael L. Cuccaro
    • 1
  • Roberto F. Tuchman
    • 2
  • Kara L. Hamilton
    • 1
  • Harry H. Wright
    • 3
  • Ruth K. Abramson
    • 3
  • Jonathan L. Haines
    • 4
  • John R. Gilbert
    • 1
  • Margaret Pericak-Vance
    • 1
  1. 1.Department of Human GeneticsUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of NeurologyMiami Children’s HospitalMiamiUSA
  3. 3.Department of NeuropsychiatryUniversity of South Carolina School of MedicineColumbiaUSA
  4. 4.Center for Human Genetics ResearchVanderbilt University Medical CenterNashvilleUSA

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