Journal of Autism and Developmental Disorders

, Volume 42, Issue 7, pp 1377–1392

Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment

  • Stephanie M. Sansone
  • Keith F. Widaman
  • Scott S. Hall
  • Allan L. Reiss
  • Amy Lightbody
  • Walter E. Kaufmann
  • Elizabeth Berry-Kravis
  • Ave Lachiewicz
  • Elaine C. Brown
  • David Hessl
Original Paper

Abstract

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3–25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

Keywords

FMR1 gene Fragile X syndrome Autism Factor analysis Rating scale Social avoidance 

Supplementary material

10803_2011_1370_MOESM1_ESM.pdf (103 kb)
Supplementary material 1 (PDF 104 kb)

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Stephanie M. Sansone
    • 1
  • Keith F. Widaman
    • 2
  • Scott S. Hall
    • 3
  • Allan L. Reiss
    • 3
  • Amy Lightbody
    • 3
  • Walter E. Kaufmann
    • 4
  • Elizabeth Berry-Kravis
    • 5
  • Ave Lachiewicz
    • 6
    • 7
  • Elaine C. Brown
    • 7
  • David Hessl
    • 1
    • 8
  1. 1.Medical Investigation of Neurodevelopmental Disorders (MIND) InstituteUniversity of California Davis Medical CenterSacramentoUSA
  2. 2.Department of PsychologyUniversity of California, DavisDavisUSA
  3. 3.Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences ResearchStanford UniversityStanfordUSA
  4. 4.Center for Genetic Disorders of Cognition and Behavior, Kennedy Krieger InstituteJohns Hopkins University School of MedicineBaltimoreUSA
  5. 5.Departments of Pediatrics, Neurological Sciences, BiochemistryRush University Medical CenterChicagoUSA
  6. 6.Departments of Pediatrics and Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA
  7. 7.Private PracticeRenoUSA
  8. 8.Department of Psychiatry and Behavioral SciencesUniversity of California, Davis, School of MedicineSacramentoUSA

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