Journal of Autism and Developmental Disorders

, Volume 42, Issue 7, pp 1326–1341

Autism Spectrum Disorder: Does Neuroimaging Support the DSM-5 Proposal for a Symptom Dyad? A Systematic Review of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging Studies

  • Laura Pina-Camacho
  • Sonia Villero
  • David Fraguas
  • Leticia Boada
  • Joost Janssen
  • Francisco J. Navas-Sánchez
  • Maria Mayoral
  • Cloe Llorente
  • Celso Arango
  • Mara Parellada
Original paper

DOI: 10.1007/s10803-011-1360-4

Cite this article as:
Pina-Camacho, L., Villero, S., Fraguas, D. et al. J Autism Dev Disord (2012) 42: 1326. doi:10.1007/s10803-011-1360-4

Abstract

A systematic review of 208 studies comprising functional magnetic resonance imaging and diffusion tensor imaging data in patients with ‘autism spectrum disorder’ (ASD) was conducted, in order to determine whether these data support the forthcoming DSM-5 proposal of a social communication and behavioral symptom dyad. Studies consistently reported abnormal function and structure of fronto-temporal and limbic networks with social and pragmatic language deficits, of temporo-parieto-occipital networks with syntactic–semantic language deficits, and of fronto-striato-cerebellar networks with repetitive behaviors and restricted interests in ASD patients. Therefore, this review partially supports the DSM-5 proposal for the ASD dyad.

Keywords

Autism spectrum disorder Autistic disorder Asperger syndrome Functional magnetic resonance imaging Diffusion tensor imaging 

Supplementary material

10803_2011_1360_MOESM1_ESM.doc (97 kb)
Supplementary material 1 (DOC 97 kb)

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Laura Pina-Camacho
    • 1
  • Sonia Villero
    • 2
  • David Fraguas
    • 3
  • Leticia Boada
    • 1
  • Joost Janssen
    • 1
  • Francisco J. Navas-Sánchez
    • 4
  • Maria Mayoral
    • 1
  • Cloe Llorente
    • 1
  • Celso Arango
    • 1
  • Mara Parellada
    • 1
  1. 1.Child and Adolescent Psychiatry DepartmentHospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAMMadridSpain
  2. 2.Unit of Child and Adolescent Mental Health, Department of PsychiatryComplejo Hospitalario Mancha Centro, Alcázar de San JuanCiudad RealSpain
  3. 3.Mental Health DepartmentComplejo Hospitalario Universitario de Albacete, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAMAlbaceteSpain
  4. 4.Department of Experimental MedicineHospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAMMadridSpain

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