Journal of Autism and Developmental Disorders

, Volume 42, Issue 6, pp 1127–1132 | Cite as

Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial

  • Stephen BentEmail author
  • Kiah Bertoglio
  • Paul Ashwood
  • Edward Nemeth
  • Robert L. Hendren
Brief Report


We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes.


Autism Clinical trial Alternative therapy 



We gratefully acknowledge the families and children who participated in this study to help advance scientific research in autism. This work was supported by grants from the MIND Institute (Dr. Hendren) and Autism Speaks, the Higgins Family Foundation, The Emch Foundation, The Taube Foundation, NIH/NCRR UCSF-CTSI Grant Number UL1 RR024131 (Dr. Bent) and the C.H.E.R.I.S.H. Foundation (Edward Nemeth), which provided funding for all HBOT treatments.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Stephen Bent
    • 1
    • 2
    • 3
    • 7
    Email author
  • Kiah Bertoglio
    • 4
  • Paul Ashwood
    • 5
  • Edward Nemeth
    • 6
  • Robert L. Hendren
    • 1
  1. 1.Department of PsychiatryUniversity of CaliforniaSan FranciscoUSA
  2. 2.Osher Center for Integrative Medicine, Department of MedicineUniversity of CaliforniaSan FranciscoUSA
  3. 3.Department of Epidemiology and BiostatisticsUniversity of CaliforniaSan FranciscoUSA
  4. 4.University of California, Irvine School of MedicineIrvineUSA
  5. 5.Department of Medical Microbiology and ImmunologyUniversity of CaliforniaDavisUSA
  6. 6.Clinical Hyperbaric Education and Research Institute for Synaptic Healing (C.H.E.R.I.S.H.) FoundationSacramentoUSA
  7. 7.San Francisco VAMCSan FranciscoUSA

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