The Autism-Spectrum Quotient—Italian Version: A Cross-Cultural Confirmation of the Broader Autism Phenotype
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The Autism Spectrum Quotient (AQ) has been used to define the ‘broader’ (BAP), ‘medium’ (MAP) and ‘narrow’ autism phenotypes (NAP). We used a new Italian version of the AQ to test if difference on AQ scores and the distribution of BAP, MAP and NAP in autism parents (n = 245) versus control parents (n = 300) were replicated in a Sicilian sample. Parents of children with autism spectrum conditions scored higher than the control parents on total AQ, social skills and communication subscales, and exhibited higher rates of BAP, MAP and NAP. We conclude that the Italian AQ is a cross-culturally reliable measure of these different phenotypes, and can be used to identify a phenotypic gradient of severity of autistic traits in families. To understand the molecular basis of these phenotypes will require its use in genetic association studies.
KeywordsAutism spectrum conditions Broader autism phenotype Autistic traits Autism-spectrum quotient
SBC, SW, and LR were supported by a grant from the MRC UK and the Nancy Lurie Marks Family Foundation during the period of this work. This work was conducted in association with the NIHR CLAHRC for Cambridgeshire and Peterborough NHS Foundation Trust. The authors thank all the parents who participated to the study. We are grateful to Dr. Valeria Mannino and Dr. Nunzia Russo for helping with parents’ recruitment. LR submitted the study in part fulfilment of her degree of PhD at the University of Catania, Italy. Some data from this work was first presented at the International Meeting for Autism Research (IMFAR), Chicago, 2009.
- APA. (1994). DSM-IV diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
- Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.PubMedCrossRefGoogle Scholar
- Bishop, D. V., Maybery, M., Maley, A., Wong, D., Hill, W., & Hallmayer, J. (2004). Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: A study using the autism-spectrum quotient. Journal of Child Psychology and Psychiatry, 45(8), 1431–1436.PubMedCrossRefGoogle Scholar
- Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill-Cawthorne, G., Allison, C., et al. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Research, 2(3), 157–177.PubMedCrossRefGoogle Scholar
- Ingersoll, B., Meyer, K., & Becker, M. W. (2010). Increased rates of depressed mood in mothers of children with ASD associated with the presence of the broader autism phenotype. Autism Research, 3, 1–6.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRefGoogle Scholar
- Ring, H., Woodbury-Smith, M., Watson, P., Wheelwright, S., & Baron-Cohen, S. (2008). Clinical heterogeneity among people with high functioning autism spectrum conditions: Evidence favouring a continuous severity gradient. Behavioral and Brain Functions, 20, 4–11.Google Scholar