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Journal of Autism and Developmental Disorders

, Volume 42, Issue 4, pp 640–642 | Cite as

Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder Using Magnetic Resonance Spectroscopy

  • Daniel A. Rossignol
  • Richard E. Frye
Letter to the editor

We read with interest the recent study by Corrigan et al. (Corrigan et al. 2011). The authors demonstrated that the prevalence of a lactate peak in the brain using magnetic resonance spectroscopy (MRS) measurements was no different between children with autism spectrum disorder (ASD) and typically developing control subjects. Since a lactate peak is a marker of mitochondrial dysfunction, the authors suggest that their study finds no evidence of mitochondrial dysfunction in children with ASD and suggest that this finding supports the idea that there is no association between mitochondrial dysfunction and ASD. While their findings are interesting and certainly add to the understanding of the complex biochemical abnormalities associated with ASD, we believe that the findings from Corrigan et al. (Corrigan et al. 2011) neither support nor refute an association between mitochondrial dysfunction and ASD for several reasons which we will outline below. We are particularly concerned that the...

Keywords

Autism Spectrum Disorder Autism Spectrum Disorder Mitochondrial Dysfunction Magnetic Resonance Spectroscopy Mitochondrial Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.International Child Development Resource CenterMelbourneUSA
  2. 2.Division of Child and Adolescent Neurology and Children’s Learning Institute, Department of PediatricsUniversity of Texas Health Science Center at HoustonHoustonUSA

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