Brief Report: Symptom Onset Patterns and Functional Outcomes in Young Children with Autism Spectrum Disorders
- 478 Downloads
This study examined the relationship between onset status and current functioning using a recently proposed onset classification system in 272 young children with autism spectrum disorder (ASD). Participants were classified into one of the following groups, based on parent report using the Autism Diagnostic Interview—Revised: Early Onset (symptoms by 12 months, no loss), Delay + Regression (symptoms by 12 months plus loss), Plateau (no early symptoms or loss), and Regression (no early symptoms, followed by loss). Findings indicate that current functioning does not differ according to onset pattern, calling into question the use of onset categorizations for prognostic purposes in children with ASD.
KeywordsAutism Regression Onset Symptom Outcomes
This research was supported by the Intramural Program of the National Institute of Mental Health (NIMH), National Institutes of Health (NIH), NIH Grants MH 07-080, 1R01MH089626, and by the M.I.N.D. Institute. The views expressed in this article do not necessarily represent the views of the NIMH, NIH, HHS, or the United States Government. The authors thank Drs. David Black, Christine Golden Williams, Lisa Joseph, and David Luckenbaugh for their helpful assistance and suggestions throughout this project. In addition, we extend our gratitude to the children and their families who volunteered their time and efforts during these research protocols.
- Le Couteur, A., Lord, C., & Rutter, M. (2003). The autism diagnostic interview—revised (ADI-R). Los Angeles, CA: Western Psychological Services.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRefGoogle Scholar
- Mullen, E. M. (1995). Mullen scales of early learning. Circle Pines, MN: American Guidance Service.Google Scholar
- Parr, J. R., Le Couteur, A., Baird, G., Rutter, M., Pickles, A., Fombonne, E., et al. (2010). Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders. doi: 10.1007/s10803-010-1055-2.
- Richler, J., Luyster, R., Risi, S., Hsu, W. L., Dawson, G., Bernier, R., et al. (2006). Is there a ‘regressive phenotype’ of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study. Journal of Autism and Developmental Disorders, 36, 299–316.PubMedCrossRefGoogle Scholar
- Sparrow, S. S., Cicchetti, D. V., & Balla, D. A. (2005). Vineland adaptive behavior scales–second edition. Circle Pines, MN: AGS Publishing.Google Scholar