Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

  • Bryan Jepson
  • Doreen Granpeesheh
  • Jonathan TarboxEmail author
  • Melissa L. Olive
  • Carol Stott
  • Scott Braud
  • J. Helen Yoo
  • Andrew Wakefield
  • Michael S. Allen
Original Paper


Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors.


Hyperbaric oxygen therapy Autism Behavioral pharmacology 



This project was funded by The Thoughtful House Center for Children, The Center for Autism and Related Disorders, and an anonymous donor.

Conflict of interest

One author (Bryan Jepson) used HBOT in some patients outside of the research trial as part of his clinical practice at the Medical Center at Thoughtful House and derived revenue from those patients. No other conflicts of interest are present.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Bryan Jepson
    • 1
  • Doreen Granpeesheh
    • 2
  • Jonathan Tarbox
    • 2
    Email author
  • Melissa L. Olive
    • 2
  • Carol Stott
    • 1
  • Scott Braud
    • 2
    • 4
  • J. Helen Yoo
    • 2
    • 3
  • Andrew Wakefield
    • 1
  • Michael S. Allen
    • 2
    • 5
  1. 1.Thoughtful House Center for ChildrenAustinUSA
  2. 2.Center for Autism and Related Disorders, Inc.TarzanaUSA
  3. 3.New York State Institute for Basic ResearchNew YorkUSA
  4. 4.HOPE ReachHollandUSA
  5. 5.Connecticut Behavioral HeathMiddletownUSA

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