Journal of Autism and Developmental Disorders

, Volume 41, Issue 3, pp 372–374 | Cite as

Brief Report: Eosinophilic Esophagitis as a Cause of Feeding Problems in Autistic Boy. The First Reported Case

  • Elżbieta Jarocka-CyrtaEmail author
  • Jolanta Wasilewska
  • Maciej Gustaw Kaczmarski
Brief Report


Unrecognized gastrointestinal disorders may contribute to the behavioral problems in non-verbal patients, but they are often overlooked since the clinical symptoms are nonspecific. Eosinophilic esophagitis (EE) is a chronic inflammatory disorder manifesting itself predominantly in reflux-type symptoms that do not respond to standard anti-reflux pharmacotherapy. Here we report the first case of EE in an autistic patient with feeding difficulties caused by exacerbated EE symptoms.


Autism Gastroesophageal reflux disease Eosinophilic esophagitis Children 


  1. American Psychiatric Association. (2000). The diagnostic and statistical manual of mental disorders (4th ed.-text revision). Washington, DC: American Psychiatric Association.Google Scholar
  2. Ashwood, P., Anthony, A., Pellicer, A. A., et al. (2003). Intestinal lymphocyte population in children with regressive autism: Evidence for extensive mucosal immunopathology. Journal of Clinical Immunology, 23, 504–517.CrossRefPubMedGoogle Scholar
  3. Böhmer, C. J. M., Klinkenberg-Knol, E. C., Niezen-de Boer, M. C., et al. (2000). Gastroesophageal reflux disease in intellectually disabled individuals: How often, how serious, haw manageable? The American Journal of Gastroenterology, 95, 1868–1872.PubMedGoogle Scholar
  4. Ferguson, D. D., & Foxx-Orenstein, A. E. (2007). Eosinophilic esophagitis: An update. Diseases of the Esophagus, 20, 2–8.CrossRefPubMedGoogle Scholar
  5. Furuta, G. T., Liacouras, C. A., Collins, M. H., et al. (2007). Eosinophilic esophagitis in children and adults: A systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology, 133, 1342–1363.CrossRefPubMedGoogle Scholar
  6. Horvath, K., Papadimitriou, J. C., Rabsztyn, A., et al. (1999). Gastrointestinal abnormalities in children with autistic disorder. The Journal of Pediatrics, 135, 559–563.CrossRefPubMedGoogle Scholar
  7. Horvath, K., & Perman, J. A. (2002). Autistic disorder and gastrointestinal disease. Current Opinion in Pediatrics, 14, 583–587.CrossRefPubMedGoogle Scholar
  8. Kelly, K. J., Lazenby, A. J., Rowe, P. C., et al. (1995). Eosinophilic esophagitis attributed to gastroesophageal reflux: Improvement with an amino acid-based formula. Gastroenterology, 109, 1503–1512.CrossRefPubMedGoogle Scholar
  9. Kodak, T., & Piazza, C. C. (2008). Assessment and behavioral treatment of feeding and sleeping disorders in children with autism spectrum disorders. Child and Adolescent Psychiatric Clinics of North America, 17, 887–905.CrossRefPubMedGoogle Scholar
  10. Martins, Y., Young, R. L., & Robson, D. C. (2008). Feeding and eating behaviors in children with autism and typically developing children. Journal of Autism and Developmental Disorders, 38(10), 1878–1887.CrossRefPubMedGoogle Scholar
  11. Mishra, B., Saddichha, S., Kumar, S., & Akhtar, S. (2007). Risperidone-induced recurrent giant urticaria. British Journal of Clinical Pharmacology, 6494, 558–559.CrossRefGoogle Scholar
  12. Noffsinger, A. E. (2009). Uptade on esophagitis. Controversial and underdiagnosed causes. Archives of Pathology and Laboratory Medicine, 133, 1087–1095.PubMedGoogle Scholar
  13. Orenstein, S. R., Shalaby, T. M., Di Lorenzo, C., et al. (2000). The spectrum of pediatric eosinophilic esophagitis beyond infancy: A clinical series of 30 children. The American Journal of Gastroenterology, 95, 1422–1430.CrossRefPubMedGoogle Scholar
  14. Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34, 433–438.CrossRefPubMedGoogle Scholar
  15. Winter, H. S., Madera, J. L., Stafford, R. J., et al. (1982). Intraepithelial eosinophils: A new diagnostic criterion for reflux esophagitis. Gastroenterology, 83, 818–823.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Elżbieta Jarocka-Cyrta
    • 1
    Email author
  • Jolanta Wasilewska
    • 1
  • Maciej Gustaw Kaczmarski
    • 1
  1. 1.Department of Pediatrics, Gastroenterology and AllergologyMedical University of BiałystokBiałystokPoland

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