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Journal of Autism and Developmental Disorders

, Volume 41, Issue 3, pp 332–340 | Cite as

Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample

  • Jeremy R. ParrEmail author
  • Ann Le Couteur
  • Gillian Baird
  • Michael Rutter
  • Andrew Pickles
  • Eric Fombonne
  • Anthony J. Bailey
  • The International Molecular Genetic Study of Autism Consortium (IMGSAC)
Original Paper
First Online:

Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.

Keywords

ASD Regression Genetics Language Development Concordance 
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Supplementary material

10803_2010_1055_MOESM1_ESM.doc (69 kb)
(DOC 69 kb)

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jeremy R. Parr
    • 1
    • 7
    Email author
  • Ann Le Couteur
    • 3
  • Gillian Baird
    • 4
  • Michael Rutter
    • 2
  • Andrew Pickles
    • 5
  • Eric Fombonne
    • 6
  • Anthony J. Bailey
    • 1
  • The International Molecular Genetic Study of Autism Consortium (IMGSAC)
    • 8
  1. 1.University Section of Child and Adolescent PsychiatryUniversity of OxfordOxfordUK
  2. 2.MRC Social Genetic and Developmental Psychiatry Centre, Institute of PsychiatryKing’s CollegeLondonUK
  3. 3.Institute of Health and SocietyNewcastle UniversityNewcastle upon TyneUK
  4. 4.Guys and St Thomas’ NHS Foundation TrustLondonUK
  5. 5.Community Based MedicineUniversity of ManchesterManchesterUK
  6. 6.Division of PsychiatryMcGill UniversityMontrealCanada
  7. 7.Institute of NeuroscienceNewcastle UniversityNewcastle upon TyneUK
  8. 8.

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