Journal of Autism and Developmental Disorders

, Volume 40, Issue 3, pp 300–316 | Cite as

Cerebellum, Language, and Cognition in Autism and Specific Language Impairment

  • Steven M. Hodge
  • Nikos Makris
  • David N. Kennedy
  • Verne S. CavinessJr.
  • James Howard
  • Lauren McGrath
  • Shelly Steele
  • Jean A. Frazier
  • Helen Tager-Flusberg
  • Gordon J. Harris
Original Paper

Abstract

We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6–13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I–V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.

Keywords

Autism Specific language impairment Cerebellum Broca’s area Asymmetry 

Notes

Acknowledgments

This work was supported in part by a grant from NIDCD to Drs. Tager-Flusberg and Harris, U19/PO1 DC 03610, which is part of the NICHD/NIDCD funded Collaborative Programs of Excellence in Autism; a grant from the NIMH to Dr. Jean Frazier, K08 MH01573; and by a Young Investigator Award funded by NARSAD and a grant from ALSA to Dr. Nikos Makris. The authors also thank Trinity Urban and Joyce Miller for proofreading comments on the manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Steven M. Hodge
    • 1
    • 2
  • Nikos Makris
    • 1
  • David N. Kennedy
    • 1
  • Verne S. CavinessJr.
    • 1
  • James Howard
    • 1
  • Lauren McGrath
    • 3
  • Shelly Steele
    • 3
  • Jean A. Frazier
    • 4
    • 5
  • Helen Tager-Flusberg
    • 3
  • Gordon J. Harris
    • 2
  1. 1.Center for Morphometric AnalysisMassachusetts General HospitalBostonUSA
  2. 2.Radiology Computer Aided Diagnostics LaboratoryMassachusetts General HospitalBostonUSA
  3. 3.Lab of Cognitive NeuroscienceBoston University School of MedicineBostonUSA
  4. 4.Department of PsychiatryHarvard Medical SchoolBostonUSA
  5. 5.Center for Child and Adolescent Development, Department of PsychiatryCambridge Health AllianceCambridgeUSA

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