Journal of Autism and Developmental Disorders

, Volume 39, Issue 12, pp 1629–1635

Open-Label Memantine in Fragile X Syndrome

  • Craig A. Erickson
  • Jennifer E. Mullett
  • Christopher J. McDougle
Original Paper


Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome (FXS). The purpose of this pilot study was to examine the effectiveness and tolerability of memantine for a number of target symptoms associated with FXS. Medical records describing open-label treatment with memantine in 6 patients with FXS and a comorbid diagnosis of PDD were reviewed. Six patients received memantine over a mean 34.7 weeks of treatment. Four of 6 (67%) patients showed global clinical benefit on ratings with the CGI-I. Symptom specific rating scales, however, showed no statistically significant improvement. Two patient developed treatment-limiting irritability on memantine. Memantine was modestly effective in several patients with FXS. Further systematic study is warranted.


Memantine Fragile X syndrome Inattention Hyperactivity Social withdrawal Irritability 


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Craig A. Erickson
    • 1
    • 2
  • Jennifer E. Mullett
    • 1
    • 2
  • Christopher J. McDougle
    • 1
    • 2
  1. 1.Department of PsychiatryIndiana University School of MedicineIndianapolisUSA
  2. 2.Christian Sarkine Autism Treatment CenterJames Whitcomb Riley Hospital for ChildrenIndianapolisUSA

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