Journal of Autism and Developmental Disorders

, Volume 39, Issue 9, pp 1252–1260

Socio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome

  • Cédric Galéra
  • Emmanuelle Taupiac
  • Sonia Fraisse
  • Sophie Naudion
  • Eva Toussaint
  • Caroline Rooryck-Thambo
  • Marie-Ange Delrue
  • Benoit Arveiler
  • Didier Lacombe
  • Manuel-Pierre Bouvard
Original Paper

Abstract

Research regarding the behavioral aspects of children with Rubinstein-Taybi syndrome (RTS) has suggested some possible behavioral patterns including autistic features. Caregivers of 39 children (mean age = 8.4 years) with RTS (49% showing abnormality in CREBBP gene) and 39 children (mean age = 8.6 years) matched on developmental level, age and gender were administered the Child Behavior Checklist and the Children’s Social Behavior Questionnaire. Children with RTS did not exhibit higher internalizing (affective and anxiety symptoms) or externalizing (disruptive symptoms) behavioral problems than expected for their age/developmental range. However, they displayed some specific behaviors: short attention span, motor stereotypies, poor coordination, and overweight. The presence of an identified CREBBP gene abnormality was possibly related to the motor difficulties through impaired motor skills learning.

Keywords

Rubinstein-Taybi syndrome Pervasive Developmental Disorder Not Otherwise Specified Socio-behavioral characteristics 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Cédric Galéra
    • 1
    • 2
  • Emmanuelle Taupiac
    • 3
  • Sonia Fraisse
    • 1
    • 3
  • Sophie Naudion
    • 1
    • 3
  • Eva Toussaint
    • 3
  • Caroline Rooryck-Thambo
    • 3
  • Marie-Ange Delrue
    • 3
  • Benoit Arveiler
    • 3
  • Didier Lacombe
    • 3
  • Manuel-Pierre Bouvard
    • 1
  1. 1.Child Psychiatry Department, Centre Hospitalier Charles-PerrensUniversity Victor SegalenBordeaux 2France
  2. 2.Centre Hospitalier Charles-PerrensPôle de pédopsychiatrie universitaireBordeauxFrance
  3. 3.Department of Medical Genetics, Centre Hospitalier Pellegrin EnfantUniversity Victor SegalenBordeaux 2France

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