Journal of Autism and Developmental Disorders

, Volume 39, Issue 8, pp 1155–1162 | Cite as

Social Anxiety in Cornelia de Lange Syndrome

  • Caroline Richards
  • Jo Moss
  • Laura O’Farrell
  • Gurmeash Kaur
  • Chris OliverEmail author
Original Paper


In this study we assessed the behavioral presentation of social anxiety in Cornelia de Lange syndrome (CdLS) using a contrast group of Cri du Chat syndrome (CdCS). Behaviors indicative of social anxiety were recorded in twelve children with CdLS (mean age = 11.00; SD = 5.15) and twelve children with CdCS (8.20; SD = 2.86) during social interaction. Lag sequential analysis revealed that participants with CdLS were significantly more likely to evidence behavior indicative of anxiety in close temporal proximity to the point at which they maintained eye contact or spoke. Individuals with CdLS demonstrate a heightened probability of anxiety related behavior during social interaction but only at the point at which social demand is high.


Anxiety Cornelia de Lange syndrome Autism spectrum disorder Behavioral phenotype Cri du Chat syndrome Social anxiety 



The authors would like to thank all of the individuals who participated in the study, the CdLS Foundation (UK and Ireland) for supporting the research and Lesley Wilkie for her contribution to data collection.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Caroline Richards
    • 1
  • Jo Moss
    • 1
  • Laura O’Farrell
    • 2
  • Gurmeash Kaur
    • 1
  • Chris Oliver
    • 1
    Email author
  1. 1.School of PsychologyUniversity of BirminghamBirminghamUK
  2. 2.Department of PsychologyUniversity of CardiffCardiffUK

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