Journal of Autism and Developmental Disorders

, Volume 38, Issue 10, pp 1827–1836 | Cite as

Regression, Developmental Trajectory and Associated Problems in Disorders in the Autism Spectrum: The SNAP Study

  • Gillian BairdEmail author
  • Tony Charman
  • Andrew Pickles
  • Susie Chandler
  • Tom Loucas
  • David Meldrum
  • Iris Carcani-Rathwell
  • Devanitha Serkana
  • Emily Simonoff
Original Paper


We report rates of regression and associated findings in a population derived group of 255 children aged 9–14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems.


SNAP Autism Regression Outcome Epilepsy Gastro-intestinal problems 



The study was funded by the Wellcome Trust and the Department of Health. We thank the expert group, Patrick Bolton, Antony Cox, Ann Gilchrist, Rebecca Landa, Ann Le Couteur, Catherine Lord, Lennart Pedersen and Michael Rutter. Thanks also to Greg Pasco, Samantha Ross, Vicky Slonims, Emma Rowley and Martha Turner for their help with assessments.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Gillian Baird
    • 1
    Email author
  • Tony Charman
    • 2
  • Andrew Pickles
    • 3
  • Susie Chandler
    • 1
  • Tom Loucas
    • 4
  • David Meldrum
    • 5
  • Iris Carcani-Rathwell
    • 6
  • Devanitha Serkana
    • 7
  • Emily Simonoff
    • 8
  1. 1.Newcomen CentreGuy’s & St. Thomas’ NHS Foundation TrustLondonUK
  2. 2.Behavioural & Brain Sciences UnitUCL Institute of Child HealthLondonUK
  3. 3.Biostatistics, Health Methodology Research GroupUniversity of ManchesterManchesterUK
  4. 4.School of Psychology and Clinical Language SciencesUniversity of ReadingReadingUK
  5. 5.Chatswood Assessment CentreSydneyAustralia
  6. 6.Greenwich Neurodevelopmental CAMHS, Oxleas NHS TrustLondonUK
  7. 7.Cheyne Child Development CentreChelsea & Westminster HospitalLondonUK
  8. 8.Department of Child and Adolescent PsychiatryInstitute of Psychiatry, King’s College LondonLondonUK

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