Intestinal Permeability and Glucagon-like peptide-2 in Children with Autism: A Controlled Pilot Study
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We measured small intestinal permeability using a lactulose:mannitol sugar permeability test in a group of children with autism, with current or previous gastrointestinal complaints. Secondly, we examined whether children with autism had an abnormal glucagon-like peptide-2 (GLP-2) response to feeding. Results were compared with sibling controls and children without developmental disabilities. We enrolled 14 children with autism, 7 developmentally normal siblings of these children and 8 healthy, developmentally normal, unrelated children. Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism.
KeywordsAutism Nutrition Intestinal permeability Glucagon-like peptide 2
We extend thanks to Laurie Wallace, Cathy Osadetz, Sue Smylie for research assistance, David Johnson MD for statistical analysis, as well as all the families who volunteered to participate in this study. This project was funded by the Jonty Foundation, Minnesota, USA.
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