Journal of Autism and Developmental Disorders

, Volume 38, Issue 1, pp 20–27

Arousal Modulation in Females with Fragile X or Turner Syndrome

  • Jane Roberts
  • Michèle M. M. Mazzocco
  • Melissa M. Murphy
  • Rudolf Hoehn-Saric
Original Paper


The present study was carried out to examine physiological arousal modulation (heart activity and skin conductance, across baseline and cognitive tasks, in females with fragile X or Turner syndrome and a comparison group of females with neither syndrome. Relative to the comparison group, for whom a greater increase in skin conductance was associated with poor arithmetic performance and less risk taking behavior, females with fragile X displayed a minimal increase in heart activity that was nevertheless associated with poor performance on mental arithmetic. In contrast, no arousal–cognitive performance relationship emerged for the group with Turner syndrome. Taken together, our findings suggest that distinct profiles of arousal modulation might be associated with cognitive deficits in these syndrome populations.


Psychophysiology Arousal Cognition Fragile X syndrome Turner syndrome 


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jane Roberts
    • 1
  • Michèle M. M. Mazzocco
    • 2
    • 3
    • 4
    • 5
  • Melissa M. Murphy
    • 2
    • 4
  • Rudolf Hoehn-Saric
    • 2
  1. 1.Frank Porter Graham Child Development InstituteUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of Population and Family Health SciencesJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Kennedy Krieger InstituteBaltimoreUSA
  5. 5.MSDPBaltimoreUSA

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