Journal of Autism and Developmental Disorders

, Volume 37, Issue 10, pp 1934–1940

Hyperserotonemia in Adults with Autistic Disorder

  • Dubravka Hranilovic
  • Zorana Bujas-Petkovic
  • Renata Vragovic
  • Tomislav Vuk
  • Karlo Hock
  • Branimir Jernej
Original Paper

DOI: 10.1007/s10803-006-0324-6

Cite this article as:
Hranilovic, D., Bujas-Petkovic, Z., Vragovic, R. et al. J Autism Dev Disord (2007) 37: 1934. doi:10.1007/s10803-006-0324-6

Abstract

Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.

Keywords

Autism Hyperserotonemia Platelet serotonin level Speech development Verbal communication 

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Dubravka Hranilovic
    • 1
    • 2
  • Zorana Bujas-Petkovic
    • 3
  • Renata Vragovic
    • 4
  • Tomislav Vuk
    • 5
  • Karlo Hock
    • 6
  • Branimir Jernej
    • 2
  1. 1.Department of Animal Physiology, Faculty of ScienceUniversity of ZagrebZagrebCroatia
  2. 2.Department of Molecular BiologyRudjer Boskovic InstituteZagrebCroatia
  3. 3.Psychiatric Hospital for Children and YouthZagrebCroatia
  4. 4.Center for autism ZagrebZagrebCroatia
  5. 5.Croatian Institute of Transfusion MedicineZagrebCroatia
  6. 6.Department of Molecular MedicineRudjer Boskovic InstituteZagrebCroatia

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